Gene Symbol: osm-12
Description: Bardet-Biedl syndrome 7 protein homolog
Alias: Bardet-Biedl syndrome 7 protein homolog
Species: Caenorhabditis elegans
Ansley S, Badano J, Blacque O, Hill J, Hoskins B, Leitch C, et al
. Basal body dysfunction is a likely cause of pleiotropic Bardet-Biedl syndrome. Nature. 2003;425:628-33 pubmed
Blacque O, Reardon M, Li C, McCarthy J, Mahjoub M, Ansley S, et al
. Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport. Genes Dev. 2004;18:1630-42 pubmed
..Our findings also suggest that some of the cardinal and secondary symptoms of BBS, such as obesity, diabetes, cardiomyopathy, and learning defects may result from cilia dysfunction. ..
Lemieux G, Liu J, Mayer N, Bainton R, Ashrafi K, Werb Z. A whole-organism screen identifies new regulators of fat storage. Nat Chem Biol. 2011;7:206-13 pubmed publisher
..Thus, our strategy identifies small molecules that are effective within the context of intact animals and reveals relationships between new pathways that operate across phyla to influence energy homeostasis. ..
Lee E, Kim H, Ditano J, Manion D, King B, Strange K. Abnormal Osmotic Avoidance Behavior in C. elegans Is Associated with Increased Hypertonic Stress Resistance and Improved Proteostasis. PLoS ONE. 2016;11:e0154156 pubmed publisher
Pan X, Ou G, Civelekoglu Scholey G, Blacque O, Endres N, Tao L, et al
. Mechanism of transport of IFT particles in C. elegans cilia by the concerted action of kinesin-II and OSM-3 motors. J Cell Biol. 2006;174:1035-45 pubmed
Kaplan O, Doroquez D, Cevik S, Bowie R, Clarke L, Sanders A, et al
. Endocytosis genes facilitate protein and membrane transport in C. elegans sensory cilia. Curr Biol. 2012;22:451-60 pubmed publisher
Nguyen P, Liou W, Hall D, Leroux M. Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J Cell Sci. 2014;127:5317-30 pubmed publisher
..We propose that differential compartmentalization of signal transduction components by ciliary proteins is important for the functions of ciliated sensory neurons. ..