Gene Symbol: nuo-2
Description: NADH Ubiquinone Oxidoreductase
Alias: NADH Ubiquinone Oxidoreductase
Species: Caenorhabditis elegans
Products:     nuo-2

Top Publications

  1. Hansen M, Hsu A, Dillin A, Kenyon C. New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS Genet. 2005;1:119-28 pubmed
    ..Thus, our current view of the genetics of aging has probably not been distorted substantially by selection bias. ..
  2. Grad L, Lemire B. Riboflavin enhances the assembly of mitochondrial cytochrome c oxidase in C. elegans NADH-ubiquinone oxidoreductase mutants. Biochim Biophys Acta. 2006;1757:115-22 pubmed
    ..We propose that one primary pathogenic mechanism of some complex I mutations is to destabilize complex IV. Enhancing complex I assembly with riboflavin results in the added benefit of partially reversing the complex IV deficit. ..
  3. Falk M, Rosenjack J, Polyak E, Suthammarak W, Chen Z, Morgan P, et al. Subcomplex Ilambda specifically controls integrated mitochondrial functions in Caenorhabditis elegans. PLoS ONE. 2009;4:e6607 pubmed publisher
    ..We demonstrate that functional consequences of complex I deficiency vary with the particular subunit that is defective. ..
  4. Nargund A, Pellegrino M, Fiorese C, Baker B, Haynes C. Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. Science. 2012;337:587-90 pubmed publisher
    ..Our results show that cells monitor mitochondrial import efficiency via ATFS-1 to coordinate the level of mitochondrial dysfunction with the protective transcriptional response. ..
  5. Schiavi A, Torgovnick A, Kell A, Megalou E, Castelein N, Guccini I, et al. Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans. Exp Gerontol. 2013;48:191-201 pubmed publisher
  6. Wirth M, Karaca S, Wenzel D, Ho L, Tishkoff D, Lombard D, et al. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Mitochondrion. 2013;13:705-20 pubmed publisher
    ..Nevertheless, no changes in mPC acetylation levels and enzymatic activity could be detected upon overexpression or loss of functional SIRT4. ..