nth-1

Summary

Gene Symbol: nth-1
Description: Endonuclease III homolog
Alias: Endonuclease III homolog
Species: Caenorhabditis elegans

Top Publications

  1. Denver D, Feinberg S, Steding C, Durbin M, Lynch M. The relative roles of three DNA repair pathways in preventing Caenorhabditis elegans mutation accumulation. Genetics. 2006;174:57-65 pubmed
    ..elegans mutation accumulation and provides evidence for the presence of pathway-specific DNA repair territories in the C. elegans genome. ..
  2. Morinaga H, Yonekura S, Nakamura N, Sugiyama H, Yonei S, Zhang Akiyama Q. Purification and characterization of Caenorhabditis elegans NTH, a homolog of human endonuclease III: essential role of N-terminal region. DNA Repair (Amst). 2009;8:844-51 pubmed publisher
    ..Indeed, DNA glycosylase activity that cleaved thymine glycol containing oligonucleotides was detected in the extract of the NTH-deficient C. elegans. ..
  3. Fensgård Ø, Kassahun H, Bombik I, Rognes T, Lindvall J, Nilsen H. A two-tiered compensatory response to loss of DNA repair modulates aging and stress response pathways. Aging (Albany NY). 2010;2:133-59 pubmed
    ..Hence, our data strongly suggests that the DNA lesions relevant for aging are repair intermediates resulting from aberrant or attempted processing by BER of lesions normally repaired by NER. ..
  4. Hunter S, Gustafson M, Margillo K, Lee S, Ryde I, Meyer J. In vivo repair of alkylating and oxidative DNA damage in the mitochondrial and nuclear genomes of wild-type and glycosylase-deficient Caenorhabditis elegans. DNA Repair (Amst). 2012;11:857-63 pubmed publisher
    ..We also failed to detect increased lethality or growth inhibition in nth-1 nematodes after exposure to oxidative or alkylating damage, suggesting the existence of at least one additional as-yet undetected glycosylase...