Gene Symbol: nos-3
Description: NanOS related
Alias: NanOS related
Species: Caenorhabditis elegans
Pacquelet A, Zanin E, Ashiono C, Gotta M. PAR-6 levels are regulated by NOS-3 in a CUL-2 dependent manner in Caenorhabditiselegans. Dev Biol. 2008;319:267-72 pubmed publisher
..Our data strongly suggest that PAR-6 levels are regulated by the CBC(FEM-1) ubiquitin ligase thereby uncovering a novel role for the FEM proteins and cullin-dependent degradation in regulating PAR proteins and polarity processes. ..
Kim K, Nykamp K, Suh N, Bachorik J, Wang L, Kimble J. Antagonism between GLD-2 binding partners controls gamete sex. Dev Cell. 2009;16:723-33 pubmed publisher
..Indeed, RNP-8 and GLD-3 antagonize each other, as evidenced by genetic cosuppression and molecular competition for GLD-2 binding. We conclude that GLD-2 and its binding partners control gamete identity. ..
Kapelle W, Reinke V. C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Genesis. 2011;49:380-91 pubmed publisher
..Additionally, MEG activity is likely more directly involved in germ cell survival than previously thought. genesis 49:380-391, 2011. ..
Kraemer B, Crittenden S, Gallegos M, Moulder G, Barstead R, Kimble J, et al
. NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegans. Curr Biol. 1999;9:1009-18 pubmed
..The three C. elegans nanos genes, like Drosophila nanos, are also critical for germ-line survival. We propose that this may have been the primitive function of nanos genes. ..
Eckmann C, Crittenden S, Suh N, Kimble J. GLD-3 and control of the mitosis/meiosis decision in the germline of Caenorhabditis elegans. Genetics. 2004;168:147-60 pubmed
..Animals homozygous for gld-3(q741) enter meiosis, but are feminized. Therefore, GLD-3 promotes meiosis primarily via its interaction with GLD-2, and it promotes spermatogenesis primarily via its interaction with FBF. ..
Arur S, Ohmachi M, Berkseth M, Nayak S, Hansen D, Zarkower D, et al
. MPK-1 ERK controls membrane organization in C. elegans oogenesis via a sex-determination module. Dev Cell. 2011;20:677-88 pubmed publisher
..In the proximal germline, sperm-dependent physiological MPK-1 activation results in phosphorylation-based inactivation of NOS-3, FEM-CUL-2-mediated degradation of TRA-1 and the promotion of membrane organization during oogenesis. ..