Gene Symbol: nos-2
Description: NanOS related
Alias: NanOS related
Species: Caenorhabditis elegans

Top Publications

  1. Subramaniam K, Seydoux G. nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegans. Development. 1999;126:4861-71 pubmed
    ..These studies demonstrate that evolutionarily distant organisms utilize conserved factors to regulate early germ cell development and survival, and that these factors include members of the nanos and pumilio gene families. ..
  2. Zalevsky J, MacQueen A, Duffy J, Kemphues K, Villeneuve A. Crossing over during Caenorhabditis elegans meiosis requires a conserved MutS-based pathway that is partially dispensable in budding yeast. Genetics. 1999;153:1271-83 pubmed
    ..We discuss a model in which HIM-14 promotes crossing over by interfering with Holliday junction branch migration. ..
  3. D AGOSTINO I, Merritt C, Chen P, Seydoux G, Subramaniam K. Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline. Dev Biol. 2006;292:244-52 pubmed
  4. Jadhav S, Rana M, Subramaniam K. Multiple maternal proteins coordinate to restrict the translation of C. elegans nanos-2 to primordial germ cells. Development. 2008;135:1803-12 pubmed publisher
    ..We propose temporal changes in the relative concentrations of POS-1 and SPN-4, through their effect on the translational status of maternal mRNAs such as nos-2, initiate germ cell-specific developmental programs in C. elegans. ..
  5. Kraemer B, Crittenden S, Gallegos M, Moulder G, Barstead R, Kimble J, et al. NANOS-3 and FBF proteins physically interact to control the sperm-oocyte switch in Caenorhabditis elegans. Curr Biol. 1999;9:1009-18 pubmed
    ..The three C. elegans nanos genes, like Drosophila nanos, are also critical for germ-line survival. We propose that this may have been the primitive function of nanos genes. ..
  6. Schaner C, Deshpande G, Schedl P, Kelly W. A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and flies. Dev Cell. 2003;5:747-57 pubmed
    ..These results indicate that genome-wide repression via a nanos-regulated, germ cell-specific chromatin organization is a conserved feature of germline maintenance during embryogenesis. ..
  7. Labbé J, Pacquelet A, Marty T, Gotta M. A genomewide screen for suppressors of par-2 uncovers potential regulators of PAR protein-dependent cell polarity in Caenorhabditis elegans. Genetics. 2006;174:285-95 pubmed
    ..Taken together, our results identify conserved components that regulate PAR protein function and also suggest a role for NOS-3 in PAR protein-dependent cell polarity. ..
  8. Katz D, Edwards T, Reinke V, Kelly W. A C. elegans LSD1 demethylase contributes to germline immortality by reprogramming epigenetic memory. Cell. 2009;137:308-20 pubmed publisher
    ..Thus, our results provide direct mechanistic insights into the processes that are required for epigenetic reprogramming between generations. ..
  9. Kapelle W, Reinke V. C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Genesis. 2011;49:380-91 pubmed publisher
    ..Additionally, MEG activity is likely more directly involved in germ cell survival than previously thought. genesis 49:380-391, 2011. ..

More Information


  1. Mainpal R, Nance J, Yanowitz J. A germ cell determinant reveals parallel pathways for germ line development in Caenorhabditis elegans. Development. 2015;142:3571-82 pubmed publisher