Gene Symbol: nmy-2
Description: Non-muscle MYosin
Alias: Non-muscle MYosin
Species: Caenorhabditis elegans

Top Publications

  1. Guo S, Kemphues K. A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans. Nature. 1996;382:455-8 pubmed
    ..We therefore conclude the NMY-2 is required for establishing cellular polarity in C. elegans embryos. ..
  2. Piekny A, Mains P. Rho-binding kinase (LET-502) and myosin phosphatase (MEL-11) regulate cytokinesis in the early Caenorhabditis elegans embryo. J Cell Sci. 2002;115:2271-82 pubmed
    ..Proteins including Rho GTPase activating protein/CYK-4 and late CYK-1, which are required for late stages of cytokinesis, function downstream of LET-502 and MEL-11. ..
  3. Cuenca A, Schetter A, Aceto D, Kemphues K, Seydoux G. Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases. Development. 2003;130:1255-65 pubmed
    ..These findings provide a model for how PAR and MEX proteins convert a transient asymmetry into a stably polarized axis. ..
  4. Munro E, Nance J, Priess J. Cortical flows powered by asymmetrical contraction transport PAR proteins to establish and maintain anterior-posterior polarity in the early C. elegans embryo. Dev Cell. 2004;7:413-24 pubmed
    ..Similar actomyosin flows accompany the establishment of PAR asymmetries that form after the one-cell stage, suggesting that actomyosin-mediated cortical flows have a general role in PAR asymmetry. ..
  5. Swan K, Severson A, Carter J, Martin P, Schnabel H, Schnabel R, et al. cyk-1: a C. elegans FH gene required for a late step in embryonic cytokinesis. J Cell Sci. 1998;111 ( Pt 14):2017-27 pubmed
    ..We discuss our findings in the context of other studies suggesting that FH genes in yeast and insects function early in cytokinesis to assemble a cleavage furrow. ..
  6. Liu J, Maduzia L, Shirayama M, Mello C. NMY-2 maintains cellular asymmetry and cell boundaries, and promotes a SRC-dependent asymmetric cell division. Dev Biol. 2010;339:366-73 pubmed publisher
    ..Finally, during a signaling-induced asymmetric cell division, NMY-2 is required for SRC-dependent phosphotyrosine signaling and acts in parallel with WNT-signaling to specify endoderm. ..
  7. Poteryaev D, Fares H, Bowerman B, Spang A. Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. EMBO J. 2007;26:301-12 pubmed
    ..We show that SAND-1 is essential for RAB-7 function at the transition from early to late endosomes, but not for RAB-7 function at lysosomes. ..
  8. Shen X, Valencia C, Gao W, Cotten S, Dong B, Huang B, et al. Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome. Cell Calcium. 2008;43:444-56 pubmed
    ..elegans. ..
  9. Walker D, Ly S, Lockwood K, Baylis H. A direct interaction between IP(3) receptors and myosin II regulates IP(3) signaling in C. elegans. Curr Biol. 2002;12:951-6 pubmed
    ..Other IP(3)-mediated processes, e.g., defecation, were unaffected. Thus it appears that interactions between IP(3)Rs and myosin are required for maintaining the specificity of IP(3) signalling in C. elegans and probably more generally. ..

More Information


  1. Piekny A, Johnson J, Cham G, Mains P. The Caenorhabditis elegans nonmuscle myosin genes nmy-1 and nmy-2 function as redundant components of the let-502/Rho-binding kinase and mel-11/myosin phosphatase pathway during embryonic morphogenesis. Development. 2003;130:5695-704 pubmed
    ..Upon completion of morphogenesis, MEL-11 again appears in the cytoplasm where it may halt actin/myosin contraction. ..
  2. Kachur T, Audhya A, Pilgrim D. UNC-45 is required for NMY-2 contractile function in early embryonic polarity establishment and germline cellularization in C. elegans. Dev Biol. 2008;314:287-99 pubmed publisher
  3. Ou G, Stuurman N, D Ambrosio M, Vale R. Polarized myosin produces unequal-size daughters during asymmetric cell division. Science. 2010;330:677-80 pubmed publisher
    ..Thus, the balance of myosin activity on the two sides of a dividing cell can govern the size and fate of the daughters. ..
  4. Poteryaev D, Squirrell J, Campbell J, White J, Spang A. Involvement of the actin cytoskeleton and homotypic membrane fusion in ER dynamics in Caenorhabditis elegans. Mol Biol Cell. 2005;16:2139-53 pubmed
    ..Both proteins have been implicated in homotypic ER membrane fusion. We provide evidence that homotypic membrane fusion is required to form the sheet structure in the early embryo. ..
  5. Werner M, Munro E, Glotzer M. Astral signals spatially bias cortical myosin recruitment to break symmetry and promote cytokinesis. Curr Biol. 2007;17:1286-97 pubmed
    ..In particular, we conclude that the astral pathway for cleavage-furrow formation involves the negative regulation of myosin distribution by astral cues. ..
  6. GOULDING M, Canman J, Senning E, Marcus A, Bowerman B. Control of nuclear centration in the C. elegans zygote by receptor-independent Galpha signaling and myosin II. J Cell Biol. 2007;178:1177-91 pubmed
    ..These results suggest that Galpha signaling and LET-99 control centration by regulating polarized actomyosin contraction...
  7. Padmanabhan A, Ong H, Zaidel Bar R. Non-junctional E-Cadherin Clusters Regulate the Actomyosin Cortex in the C. elegans Zygote. Curr Biol. 2017;27:103-112 pubmed publisher