Gene Symbol: nhr-67
Description: Nuclear hormone receptor family member nhr-67
Alias: Nuclear hormone receptor family member nhr-67
Species: Caenorhabditis elegans

Top Publications

  1. Gissendanner C, Crossgrove K, Kraus K, Maina C, Sluder A. Expression and function of conserved nuclear receptor genes in Caenorhabditis elegans. Dev Biol. 2004;266:399-416 pubmed
    ..Together, these analyses provide a foundation for further dissecting the role of NRs in nematode development as well as for evaluating conservation of NR functions among the Metazoa. ..
  2. Lehner B, Calixto A, Crombie C, Tischler J, Fortunato A, Chalfie M, et al. Loss of LIN-35, the Caenorhabditis elegans ortholog of the tumor suppressor p105Rb, results in enhanced RNA interference. Genome Biol. 2006;7:R4 pubmed
    ..As lin-35 is the worm ortholog of the mammalian tumor suppressor gene p105Rb, misregulation of RNAi may be important during human oncogenesis. ..
  3. DeMeo S, Lombel R, Cronin M, Smith E, Snowflack D, Reinert K, et al. Specificity of DNA-binding by the FAX-1 and NHR-67 nuclear receptors of Caenorhabditis elegans is partially mediated via a subclass-specific P-box residue. BMC Mol Biol. 2008;9:2 pubmed publisher
    ..The apparent conservation of DNA-binding properties between vertebrate and nematode NR2E receptors allows for the possibility of evolutionarily-conserved regulatory patterns. ..
  4. Sarin S, Antonio C, Tursun B, Hobert O. The C. elegans Tailless/TLX transcription factor nhr-67 controls neuronal identity and left/right asymmetric fate diversification. Development. 2009;136:2933-44 pubmed publisher
  5. Matus D, Lohmer L, Kelley L, Schindler A, Kohrman A, Barkoulas M, et al. Invasive Cell Fate Requires G1 Cell-Cycle Arrest and Histone Deacetylase-Mediated Changes in Gene Expression. Dev Cell. 2015;35:162-74 pubmed publisher
    ..Together, these results suggest that invasive cell fate requires G1 arrest and that strategies targeting both G1-arrested and actively cycling cells may be needed to halt metastatic cancer. ..
  6. Fernandes J, Sternberg P. The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva. PLoS Genet. 2007;3:e69 pubmed
    ..We postulate that the differential levels and combinatorial patterns of lin-11, cog-1, and nhr-67 expression are a part of a regulatory code for the mature vulval cell types...
  7. Kato M, Sternberg P. The C. elegans tailless/Tlx homolog nhr-67 regulates a stage-specific program of linker cell migration in male gonadogenesis. Development. 2009;136:3907-15 pubmed publisher
    ..We propose that there is a basal migration program utilized throughout LC migration that is modified by stage-specific regulators such as nhr-67. ..
  8. Verghese E, Schocken J, Jacob S, Wimer A, Royce R, Nesmith J, et al. The tailless ortholog nhr-67 functions in the development of the C. elegans ventral uterus. Dev Biol. 2011;356:516-28 pubmed publisher