Gene Symbol: nhr-23
Description: Nuclear hormone receptor family member nhr-23
Alias: Nuclear hormone receptor family member nhr-23
Species: Caenorhabditis elegans
Kostrouchova M, Krause M, Kostrouch Z, Rall J. Nuclear hormone receptor CHR3 is a critical regulator of all four larval molts of the nematode Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2001;98:7360-5 pubmed
..These results define CHR3 as a critical regulator of all C. elegans molts and begin to define the molecular pathway for its function. ..
Brooks D, Appleford P, Murray L, Isaac R. An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin-converting enzyme family that lacks a metallopeptidase active site. J Biol Chem. 2003;278:52340-6 pubmed
Asahina M, Valenta T, Silhankova M, Korinek V, Jindra M. Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad. Dev Cell. 2006;11:203-11 pubmed
..This balance relies on direct crossregulation between NHR-25 and the distinct beta-catenin proteins WRM-1 and SYS-1. The nuclear receptor-beta-catenin interaction may be an ancient mechanism of cell-fate decision. ..
Sahu S, Lewis J, Patel I, Bozdag S, Lee J, Leclerc J, et al
. Genomic analysis of immune response against Vibrio cholerae hemolysin in Caenorhabditis elegans. PLoS ONE. 2012;7:e38200 pubmed publisher
..Our results suggest that VCC is a major virulence factor, which induces a wide variety of immune response- related genes during V. cholerae infection in C. elegans...
Kostrouchova M, Krause M, Kostrouch Z, Rall J. CHR3: a Caenorhabditis elegans orphan nuclear hormone receptor required for proper epidermal development and molting. Development. 1998;125:1617-26 pubmed
Silhankova M, Jindra M, Asahina M. Nuclear receptor NHR-25 is required for cell-shape dynamics during epidermal differentiation in Caenorhabditis elegans. J Cell Sci. 2005;118:223-32 pubmed
..Silencing of nhr-25 also disturbs epidermal ultrastructure, which is probably the cause of compromised cuticle secretion and molting. Cell shape dynamics and molting thus represent distinct roles for NHR-25 in epidermal development. ..
Hayes G, Frand A, Ruvkun G. The mir-84 and let-7 paralogous microRNA genes of Caenorhabditis elegans direct the cessation of molting via the conserved nuclear hormone receptors NHR-23 and NHR-25. Development. 2006;133:4631-41 pubmed
..The synergistic action of miRNA paralogs in development may be a general feature of the diversified miRNA gene family. ..
Kouns N, Nakielna J, Behenský F, Krause M, Kostrouch Z, Kostrouchova M. NHR-23 dependent collagen and hedgehog-related genes required for molting. Biochem Biophys Res Commun. 2011;413:515-20 pubmed publisher
..Our results indicate that NHR-23 is a critical co-regulator of functionally linked genes involved in growth and molting and reveal evolutionary parallels among the ecdysozoa. ..