Gene Symbol: ndc-80
Description: Kinetochore protein ndc-80
Alias: Kinetochore protein ndc-80
Species: Caenorhabditis elegans
Cheerambathur D, Gassmann R, Cook B, Oegema K, Desai A. Crosstalk between microtubule attachment complexes ensures accurate chromosome segregation. Science. 2013;342:1239-42 pubmed publisher
..Thus, the conversion from initial dynein-mediated, lateral attachments to correctly oriented, Ndc80-mediated end-coupled attachments is actively controlled. ..
Cheeseman I, Niessen S, Anderson S, Hyndman F, Yates J, Oegema K, et al
. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 2004;18:2255-68 pubmed
..Thus, this protein network is a conserved constituent of the outer kinetochore, and the functions defined by our analysis in C. elegans are likely to be widely relevant. ..
Kubota Y, Sano M, Goda S, Suzuki N, Nishiwaki K. The conserved oligomeric Golgi complex acts in organ morphogenesis via glycosylation of an ADAM protease in C. elegans. Development. 2006;133:263-73 pubmed
..Furthermore, COGC-3 requires MIG-17 activity for its action in DTC migration. Our findings demonstrate that COG complex-dependent glycosylation of an ADAM protease plays a crucial role in determining organ shape. ..
Cheeseman I, Chappie J, Wilson Kubalek E, Desai A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell. 2006;127:983-97 pubmed
..Based on these findings, we propose that the conserved KMN network constitutes the core microtubule-binding site of the kinetochore. ..
Gassmann R, Essex A, Hu J, Maddox P, Motegi F, Sugimoto A, et al
. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008;22:2385-99 pubmed publisher
Dumont J, Oegema K, Desai A. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat Cell Biol. 2010;12:894-901 pubmed publisher
..We suggest that separation is controlled by a meiosis-specific chromosomal domain to coordinate cohesin removal and chromosome segregation. ..
Wilson Kubalek E, Cheeseman I, Milligan R. Structural comparison of the Caenorhabditis elegans and human Ndc80 complexes bound to microtubules reveals distinct binding behavior. Mol Biol Cell. 2016;27:1197-203 pubmed publisher
..elegansNdc80 complex tilts more toward the adjacent protofilament. These structural differences in the Ndc80 complex between different species may play significant roles in the nature of kinetochore-microtubule interactions. ..
Desai A, Rybina S, MULLER REICHERT T, Shevchenko A, Shevchenko A, Hyman A, et al
. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 2003;17:2421-35 pubmed
..Thus, KNL-1 plays a central role in translating the initiation of kinetochore assembly by CeCENP-A and CeCENP-C into the formation of a functional microtubule-binding interface. ..
Connolly A, Sugioka K, Chuang C, Lowry J, Bowerman B. KLP-7 acts through the Ndc80 complex to limit pole number in C. elegans oocyte meiotic spindle assembly. J Cell Biol. 2015;210:917-32 pubmed publisher