Gene Symbol: mtm-6
Description: MTM (myotubularin) family;Myotubularin-related protein 6
Alias: MTM (myotubularin) family;Myotubularin-related protein 6
Species: Caenorhabditis elegans
Xue Y, Fares H, Grant B, Li Z, Rose A, Clark S, et al
. Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans. J Biol Chem. 2003;278:34380-6 pubmed
..elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34, indicates that MTMs do not simply turn off VPS34 but unexpectedly also function as positive regulators of biological processes. ..
Dang H, Li Z, Skolnik E, Fares H. Disease-related myotubularins function in endocytic traffic in Caenorhabditis elegans. Mol Biol Cell. 2004;15:189-96 pubmed
..We demonstrate that MTM-6 and MTM-9 function as part of a complex to regulate an endocytic pathway that involves the Arf6 GTPase, and we define protein domains required for MTM-6 activity. ..
Silhankova M, Port F, Harterink M, Basler K, Korswagen H. Wnt signalling requires MTM-6 and MTM-9 myotubularin lipid-phosphatase function in Wnt-producing cells. EMBO J. 2010;29:4094-105 pubmed publisher
..We conclude that regulation of endosomal trafficking by the MTM-6/MTM-9 myotubularin complex is required for the retromer-dependent recycling of MIG-14/Wls and Wnt secretion. ..
Fares H, Greenwald I. Genetic analysis of endocytosis in Caenorhabditis elegans: coelomocyte uptake defective mutants. Genetics. 2001;159:133-45 pubmed
Maekawa M, Terasaka S, Mochizuki Y, Kawai K, Ikeda Y, Araki N, et al
. Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis. Proc Natl Acad Sci U S A. 2014;111:E978-87 pubmed publisher
..We propose that the sequential breakdown of PI(3,4,5)P3 ? PI(3,4)P2 ? PI(3)P ? PI controls macropinocytosis through specific effectors of the intermediate phosphoinositides. ..
Ericson V, Spilker K, Tugizova M, Shen K. MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans. PLoS ONE. 2014;9:e114501 pubmed publisher
..We conclude that regulation of secretion of different Wnt ligands can use different components. Additionally, we present a novel neuronal function for MTM-6. ..