Gene Symbol: mtm-3
Description: Myotubularin-related protein 3
Alias: Myotubularin-related protein 3
Species: Caenorhabditis elegans
Ma J, Zeng F, Ho W, Teng L, Li Q, Fu X, et al
. Characterization and functional studies of a FYVE domain-containing phosphatase in C. elegans. J Cell Biochem. 2008;104:1843-52 pubmed publisher
..This study thus reveals an important role of the MTM phosphatases in maintaining muscle function, which may have clinical implications in prevention and treatment of sarcopenia. ..
Xue Y, Fares H, Grant B, Li Z, Rose A, Clark S, et al
. Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans. J Biol Chem. 2003;278:34380-6 pubmed
..elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34, indicates that MTMs do not simply turn off VPS34 but unexpectedly also function as positive regulators of biological processes. ..
Zou W, Lu Q, Zhao D, Li W, Mapes J, Xie Y, et al
. Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet. 2009;5:e1000679 pubmed publisher
..We propose that MTM-1 negatively regulates cell corpse engulfment through the CED-5/CED-12/CED-10 module by dephosphorylating PtdIns(3)P on the plasma membrane. ..
Yu X, Ma J, Lin F, Zhao W, Fu X, Zhao Z. Myotubularin family phosphatase ceMTM3 is required for muscle maintenance by preventing excessive autophagy in Caenorhabditis elegans. BMC Cell Biol. 2012;13:28 pubmed publisher
..Our data suggest an important role of ceMTM3 in regulating autophagy and maintaining muscle fibers. This study may have clinical implications for prevention and treatment of sarcopenia. ..
Wu Y, Cheng S, Zhao H, Zou W, Yoshina S, Mitani S, et al
. PI3P phosphatase activity is required for autophagosome maturation and autolysosome formation. EMBO Rep. 2014;15:973-81 pubmed publisher
..Our data reveal critical roles of PtdIns3P turnover in autophagosome maturation and/or autolysosome formation. ..