Gene Symbol: mtm-1
Description: Myotubularin-related protein 1
Alias: Myotubularin-related protein 1
Species: Caenorhabditis elegans
Zou W, Lu Q, Zhao D, Li W, Mapes J, Xie Y, et al
. Caenorhabditis elegans myotubularin MTM-1 negatively regulates the engulfment of apoptotic cells. PLoS Genet. 2009;5:e1000679 pubmed publisher
..We propose that MTM-1 negatively regulates cell corpse engulfment through the CED-5/CED-12/CED-10 module by dephosphorylating PtdIns(3)P on the plasma membrane. ..
Xue Y, Fares H, Grant B, Li Z, Rose A, Clark S, et al
. Genetic analysis of the myotubularin family of phosphatases in Caenorhabditis elegans. J Biol Chem. 2003;278:34380-6 pubmed
..elegans MTMs play essential roles in coelomocyte endocytosis, a process that also requires VPS34, indicates that MTMs do not simply turn off VPS34 but unexpectedly also function as positive regulators of biological processes. ..
Neukomm L, Nicot A, Kinchen J, Almendinger J, Pinto S, Zeng S, et al
. The phosphoinositide phosphatase MTM-1 regulates apoptotic cell corpse clearance through CED-5-CED-12 in C. elegans. Development. 2011;138:2003-14 pubmed publisher
..Finally, we show that the CED-12 PH domain can bind to PtdIns(3,5)P(2) (one target of MTM-1 phosphatase activity), suggesting that MTM-1 might regulate CED-12 recruitment to the plasma membrane. ..
Lu N, Shen Q, Mahoney T, Neukomm L, Wang Y, Zhou Z. Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. PLoS Biol. 2012;10:e1001245 pubmed publisher
..They further shed light on how the temporally controlled reversible phosphorylation of phosphoinositides regulates the progression of multi-step cellular events...
Cheng S, Wang K, Zou W, Miao R, Huang Y, Wang H, et al
. PtdIns(4,5)Pâ‚‚ and PtdIns3P coordinate to regulate phagosomal sealing for apoptotic cell clearance. J Cell Biol. 2015;210:485-502 pubmed publisher
..Our findings support a coincidence detection mechanism by which phagosomal sealing is regulated and coupled with conversion from PtdIns(4,5)P2 enrichment on unsealed phagosomes to PtdIns3P enrichment on fully sealed phagosomes. ..