mom-5

Summary

Gene Symbol: mom-5
Description: Protein mom-5
Alias: Protein mom-5
Species: Caenorhabditis elegans

Top Publications

  1. Rocheleau C, Downs W, Lin R, Wittmann C, Bei Y, Cha Y, et al. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell. 1997;90:707-16 pubmed
    ..We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres. ..
  2. Schlesinger A, Shelton C, Maloof J, Meneghini M, Bowerman B. Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. Genes Dev. 1999;13:2028-38 pubmed
    ..Orientation of the mitotic spindle does not require gene transcription in EMS, suggesting that Wnt signaling may directly target the cytoskeleton in a responding cell. ..
  3. Gleason J, Szyleyko E, Eisenmann D. Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development. Dev Biol. 2006;298:442-57 pubmed
    ..p lineage. Here, too, we found that four of five Wnt receptors can influence P7.p orientation, suggesting that a surprising amount of functional redundancy exists in Wnt signaling during C. elegans vulval induction...
  4. Zinovyeva A, Yamamoto Y, Sawa H, Forrester W. Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development. Genetics. 2008;179:1357-71 pubmed publisher
    ..Finally, we find striking differences between the phenotypes of the Wnt quintuple and Frizzled quadruple mutants. ..
  5. Park F, Tenlen J, Priess J. C. elegans MOM-5/frizzled functions in MOM-2/Wnt-independent cell polarity and is localized asymmetrically prior to cell division. Curr Biol. 2004;14:2252-8 pubmed
    ..These localization patterns suggest a parallel between MOM-5/Frizzled and the roles of Drosophila Frizzled in planar polarity and dorsal enclosure. ..
  6. Bei Y, Hogan J, Berkowitz L, Soto M, Rocheleau C, Pang K, et al. SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. Dev Cell. 2002;3:113-25 pubmed
    ..Our findings suggest that Wnt and Src signaling function in parallel to control developmental outcomes within a single responding cell. ..
  7. Walston T, Tuskey C, Edgar L, Hawkins N, Ellis G, Bowerman B, et al. Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev Cell. 2004;7:831-41 pubmed
  8. Phillips B, Kidd A, King R, Hardin J, Kimble J. Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2007;104:3231-6 pubmed
    ..We suggest a two-pronged pathway for control of SYS-1:POP-1, which can robustly accomplish differential gene expression in daughters of an asymmetric cell division. ..
  9. Shin T, Yasuda J, Rocheleau C, Lin R, Soto M, Bei Y, et al. MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans. Mol Cell. 1999;4:275-80 pubmed
    ..These findings suggest that anterior/posterior polarity signaling in C. elegans may involve a MAP kinase-like signaling mechanism. ..

More Information

Publications19

  1. Moffat L, Robinson R, Bakoulis A, Clark S. The conserved transmembrane RING finger protein PLR-1 downregulates Wnt signaling by reducing Frizzled, Ror and Ryk cell-surface levels in C. elegans. Development. 2014;141:617-28 pubmed publisher
    ..We propose that PLR-1 downregulates Wnt receptor surface levels via lysine ubiquitylation of Frizzled to coordinate spatial and temporal responses to Wnts during neuronal development. ..
  2. Schneider J, Skelton R, Von Stetina S, Middelkoop T, van Oudenaarden A, Korswagen H, et al. UNC-4 antagonizes Wnt signaling to regulate synaptic choice in the C. elegans motor circuit. Development. 2012;139:2234-45 pubmed publisher
    ..The existence of comparable Wnt gradients in the vertebrate spinal cord could reflect similar roles for Wnt signaling in vertebrate motor circuit assembly. ..
  3. Cabello J, Neukomm L, Günesdogan U, Burkart K, Charette S, Lochnit G, et al. The Wnt pathway controls cell death engulfment, spindle orientation, and migration through CED-10/Rac. PLoS Biol. 2010;8:e1000297 pubmed publisher
    ..Taken together, our results indicate that in multiple developmental processes, CED-10/Rac can link polar signals mediated by the Wnt pathway to rearrangements of the cytoskeleton. ..
  4. Levy Strumpf N, Krizus M, Zheng H, Brown L, Culotti J. The Wnt Frizzled Receptor MOM-5 Regulates the UNC-5 Netrin Receptor through Small GTPase-Dependent Signaling to Determine the Polarity of Migrating Cells. PLoS Genet. 2015;11:e1005446 pubmed publisher
  5. Chien S, Gurling M, Kim C, Craft T, FORRESTER W, Garriga G. Autonomous and nonautonomous regulation of Wnt-mediated neuronal polarity by the C. elegans Ror kinase CAM-1. Dev Biol. 2015;404:55-65 pubmed publisher
    ..In this model, loss of CAM-1 results in increased levels of Wnts that act through other Wnt receptors, masking CAM-1's autonomous role as a Wnt receptor. ..
  6. Sawyer J, Glass S, Li T, Shemer G, White N, Starostina N, et al. Overcoming redundancy: an RNAi enhancer screen for morphogenesis genes in Caenorhabditis elegans. Genetics. 2011;188:549-64 pubmed publisher
    ..Our results implicate new genes in C. elegans gastrulation, and they show that an RNAi-based enhancer screen in C. elegans can be used as an efficient means to identify important but redundant or partially redundant developmental genes. ..
  7. Witze E, Field E, Hunt D, Rothman J. C. elegans pur alpha, an activator of end-1, synergizes with the Wnt pathway to specify endoderm. Dev Biol. 2009;327:12-23 pubmed publisher
    ..These findings imply that PLP-1 acts as a transcriptional activator of end-1 expression that may be modulated by MAPK signaling to promote endoderm development. ..
  8. Pan C, Howell J, Clark S, Hilliard M, Cordes S, Bargmann C, et al. Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans. Dev Cell. 2006;10:367-77 pubmed
    ..Our results indicate that Wnts play a key role in A/P guidance in C. elegans and employ distinct mechanisms to regulate different migrations. ..
  9. Hawkins N, Ellis G, Bowerman B, Garriga G. MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions. Dev Biol. 2005;284:246-59 pubmed
    ..Although all neurons in C. elegans are produced by an invariant pattern of cell divisions, our results indicate that cell signaling may contribute to asymmetric neuroblast division during embryogenesis. ..
  10. Rocheleau C, Yasuda J, Shin T, Lin R, Sawa H, Okano H, et al. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell. 1999;97:717-26 pubmed
    ..This activation leads to phosphorylation of POP-1 and to apparent changes in its subcellular localization. Our findings provide evidence for novel regulatory avenues for an evolutionarily conserved Wnt/WG signaling pathway. ..