Gene Symbol: mom-4
Description: Mitogen-activated protein kinase kinase kinase mom-4
Alias: Mitogen-activated protein kinase kinase kinase mom-4
Species: Caenorhabditis elegans
Shin T, Yasuda J, Rocheleau C, Lin R, Soto M, Bei Y, et al
. MOM-4, a MAP kinase kinase kinase-related protein, activates WRM-1/LIT-1 kinase to transduce anterior/posterior polarity signals in C. elegans. Mol Cell. 1999;4:275-80 pubmed
..These findings suggest that anterior/posterior polarity signaling in C. elegans may involve a MAP kinase-like signaling mechanism. ..
Ono K, Ohtomo T, Sato S, Sugamata Y, Suzuki M, Hisamoto N, et al
. An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK. J Biol Chem. 2001;276:24396-400 pubmed
..These results suggest that the Phe or Ala residue within the conserved motif of the TAB1-related proteins is important for interaction with and activation of specific TAK1 MAPKKK family members in vivo. ..
Putzke A, Rothman J. Repression of Wnt signaling by a Fer-type nonreceptor tyrosine kinase. Proc Natl Acad Sci U S A. 2010;107:16154-9 pubmed publisher
..These findings highlight a role for a Fer-type kinase in setting the proper levels of Wnt signaling and demonstrate the importance of this modulation in ensuring appropriate cell division. ..
Yang X, Karhadkar T, Medina J, Robertson S, Lin R. Î²-Catenin-related protein WRM-1 is a multifunctional regulatory subunit of the LIT-1 MAPK complex. Proc Natl Acad Sci U S A. 2015;112:E137-46 pubmed publisher
..To our knowledge, this is the first report of a MAP3K directly activating a MAPK by phosphorylation within the activation loop. This study should help uncover novel and as yet underappreciated functions of vertebrate Î²-catenin. ..
Meneghini M, Ishitani T, Carter J, Hisamoto N, Ninomiya Tsuji J, Thorpe C, et al
. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature. 1999;399:793-7 pubmed
..These functions are likely to be conserved in vertebrates, as TAK1 and NLK can downregulate HMG-domain-containing proteins related to POP-1. ..
Bei Y, Hogan J, Berkowitz L, Soto M, Rocheleau C, Pang K, et al
. SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. Dev Cell. 2002;3:113-25 pubmed
..Our findings suggest that Wnt and Src signaling function in parallel to control developmental outcomes within a single responding cell. ..
Smit L, Baas A, Kuipers J, Korswagen H, van de Wetering M, Clevers H. Wnt activates the Tak1/Nemo-like kinase pathway. J Biol Chem. 2004;279:17232-40 pubmed
..Thus, Wnt signal transduction through the canonical pathway activates beta-catenin/TCF, whereas Wnt signal transduction through the Tak1 pathway phosphorylates and inhibits TCF, which might function as a feedback mechanism. ..
Nakamura K, Kim S, Ishidate T, Bei Y, Pang K, Shirayama M, et al
. Wnt signaling drives WRM-1/beta-catenin asymmetries in early C. elegans embryos. Genes Dev. 2005;19:1749-54 pubmed
..We show that both PRY-1/Axin and the nuclear exportin homolog IMB-4/CRM-1 antagonize signaling. These findings reveal how Wnt signals direct the asymmetric localization of beta-catenin during polarized cell division. ..
Xu A, Shi G, Liu F, Ge B. Caenorhabditis elegans mom-4 is required for the activation of the p38 MAPK signaling pathway in the response to Pseudomonas aeruginosa infection. Protein Cell. 2013;4:53-61 pubmed publisher
..elegans is required for P. aeruginosa resistance, but not through the regulation of DLK-1. In summary, our results indicate that different upstream MAPKKKs or MAPKKs regulate the activation of PMK-1 in response to P. Aeruginosa. ..