mom-1

Summary

Gene Symbol: mom-1
Description: Protein-serine O-palmitoleoyltransferase porcupine
Alias: Protein-serine O-palmitoleoyltransferase porcupine
Species: Caenorhabditis elegans

Top Publications

  1. Thorpe C, Schlesinger A, Carter J, Bowerman B. Wnt signaling polarizes an early C. elegans blastomere to distinguish endoderm from mesoderm. Cell. 1997;90:695-705 pubmed
    ..Defective mitotic spindle orientations in mom mutant embryos indicate that Wnt signaling influences cytoskeletal polarity in blastomeres throughout the early embryo. ..
  2. Rocheleau C, Downs W, Lin R, Wittmann C, Bei Y, Cha Y, et al. Wnt signaling and an APC-related gene specify endoderm in early C. elegans embryos. Cell. 1997;90:707-16 pubmed
    ..We present evidence that there may be partially redundant inputs into endoderm specification and that a subset of these genes appear also to function in determining cytoskeletal polarity in certain early blastomeres. ..
  3. Meneghini M, Ishitani T, Carter J, Hisamoto N, Ninomiya Tsuji J, Thorpe C, et al. MAP kinase and Wnt pathways converge to downregulate an HMG-domain repressor in Caenorhabditis elegans. Nature. 1999;399:793-7 pubmed
    ..These functions are likely to be conserved in vertebrates, as TAK1 and NLK can downregulate HMG-domain-containing proteins related to POP-1. ..
  4. Schlesinger A, Shelton C, Maloof J, Meneghini M, Bowerman B. Wnt pathway components orient a mitotic spindle in the early Caenorhabditis elegans embryo without requiring gene transcription in the responding cell. Genes Dev. 1999;13:2028-38 pubmed
    ..Orientation of the mitotic spindle does not require gene transcription in EMS, suggesting that Wnt signaling may directly target the cytoskeleton in a responding cell. ..
  5. Hofmann K. A superfamily of membrane-bound O-acyltransferases with implications for wnt signaling. Trends Biochem Sci. 2000;25:111-2 pubmed
  6. Bei Y, Hogan J, Berkowitz L, Soto M, Rocheleau C, Pang K, et al. SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. Dev Cell. 2002;3:113-25 pubmed
    ..Our findings suggest that Wnt and Src signaling function in parallel to control developmental outcomes within a single responding cell. ..