Gene Symbol: mlk-1
Description: Mitogen-activated protein kinase kinase kinase mlk-1
Alias: Mitogen-activated protein kinase kinase kinase mlk-1
Species: Caenorhabditis elegans
Hammarlund M, Nix P, Hauth L, Jorgensen E, Bastiani M. Axon regeneration requires a conserved MAP kinase pathway. Science. 2009;323:802-6 pubmed publisher
..We conclude that after axon injury, activation of this MAP kinase cascade is required to switch the mature neuron from an aplastic state to a state capable of growth. ..
Nix P, Hisamoto N, Matsumoto K, Bastiani M. Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways. Proc Natl Acad Sci U S A. 2011;108:10738-43 pubmed publisher
..These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3(p38) and KGB-1(JNK). ..
Fujiki K, Mizuno T, Hisamoto N, Matsumoto K. The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response. Mol Cell Biol. 2010;30:995-1003 pubmed publisher
..These results suggest that MAX-2 and MIG-2 play a crucial role in mediating the heavy metal stress response regulated by the KGB-1 pathway. ..
Li C, Hisamoto N, Nix P, Kanao S, Mizuno T, Bastiani M, et al
. The growth factor SVH-1 regulates axon regeneration in C. elegans via the JNK MAPK cascade. Nat Neurosci. 2012;15:551-7 pubmed publisher
..Thus, SVH-1-SVH-2 signaling via activation of the MAPK pathway acts to coordinate neuron regeneration response after axon injury. ..
Pastuhov S, Fujiki K, Nix P, Kanao S, Bastiani M, Matsumoto K, et al
. Endocannabinoid-Go? signalling inhibits axon regeneration in Caenorhabditis elegans by antagonizing Gq?-PKC-JNK signalling. Nat Commun. 2012;3:1136 pubmed publisher
..Our results show that arachidonoyl ethanolamide induction of a G protein signal transduction pathway has a role in the inhibition of post-development axon regeneration...
Uno M, Honjoh S, Matsuda M, Hoshikawa H, Kishimoto S, Yamamoto T, et al
. A fasting-responsive signaling pathway that extends life span in C. elegans. Cell Rep. 2013;3:79-91 pubmed publisher
..Our results thus identify a fasting-responsive KGB-1/AP-1 signaling pathway, which, together with DAF-16, causes transcriptional changes that mediate longevity, partly through regulating proteostasis. ..
Pellegrino M, Nargund A, Kirienko N, Gillis R, Fiorese C, Haynes C. Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection. Nature. 2014;516:414-7 pubmed publisher
..We propose that ATFS-1 import efficiency and the UPR(mt) is a means to detect pathogens that target mitochondria and initiate a protective innate immune response. ..
Hisamoto N, Nagamori Y, Shimizu T, Pastuhov S, Matsumoto K. The C. elegans Discoidin Domain Receptor DDR-2 Modulates the Met-like RTK-JNK Signaling Pathway in Axon Regeneration. PLoS Genet. 2016;12:e1006475 pubmed publisher
..These results suggest that DDR-2 modulates the SVH-2-JNK pathway via SHC-1. We thus identify two different RTK signaling networks that play coordinated roles in the regulation of axonal regeneration. ..