mksr-2

Summary

Gene Symbol: mksr-2
Description: MecKel Syndrome 1 (MKS1)-Related
Alias: MecKel Syndrome 1 (MKS1)-Related
Species: Caenorhabditis elegans

Top Publications

  1. Williams C, Winkelbauer M, Schafer J, Michaud E, Yoder B. Functional redundancy of the B9 proteins and nephrocystins in Caenorhabditis elegans ciliogenesis. Mol Biol Cell. 2008;19:2154-68 pubmed publisher
    ..Together, these data suggest that the human homologues of the novel B9 genes B9D2 and B9D1 will be strong candidate loci for pathologies in human MKS, NPHP, and JBTS. ..
  2. Bialas N, Inglis P, Li C, Robinson J, Parker J, Healey M, et al. Functional interactions between the ciliopathy-associated Meckel syndrome 1 (MKS1) protein and two novel MKS1-related (MKSR) proteins. J Cell Sci. 2009;122:611-24 pubmed publisher
    ..Our findings therefore demonstrate functional interactions between a novel family of proteins associated with basal bodies or cilia, providing new insights into the molecular etiology of a pleiotropic human disorder. ..
  3. Williams C, Li C, Kida K, Inglis P, Mohan S, Semenec L, et al. MKS and NPHP modules cooperate to establish basal body/transition zone membrane associations and ciliary gate function during ciliogenesis. J Cell Biol. 2011;192:1023-41 pubmed publisher
  4. Nguyen P, Liou W, Hall D, Leroux M. Ciliopathy proteins establish a bipartite signaling compartment in a C. elegans thermosensory neuron. J Cell Sci. 2014;127:5317-30 pubmed publisher
    ..We propose that differential compartmentalization of signal transduction components by ciliary proteins is important for the functions of ciliated sensory neurons. ..

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