Gene Symbol: mkk-4
Description: MAP kinase kinase mkk-4
Alias: MAP kinase kinase mkk-4
Species: Caenorhabditis elegans
Nakata K, Abrams B, Grill B, Goncharov A, Huang X, Chisholm A, et al
. Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development. Cell. 2005;120:407-20 pubmed
..DLK-1 protein levels are elevated in rpm-1 mutants. The RPM-1 RING finger can stimulate ubiquitination of DLK-1. Our data reveal a presynaptic role of a previously unknown p38 MAP kinase cascade. ..
Berman K, Hutchison M, Avery L, Cobb M. kin-18, a C. elegans protein kinase involved in feeding. Gene. 2001;279:137-47 pubmed
..We have also identified a C. elegans gene that encodes a protein kinase similar to mammalian MAPK/ERK Kinase (MEK) 4 whose promoter is active in the pharynx. It is phosphorylated by TAO1 in vitro and physically interacts with TAO1. ..
Nix P, Hisamoto N, Matsumoto K, Bastiani M. Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways. Proc Natl Acad Sci U S A. 2011;108:10738-43 pubmed publisher
..These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3(p38) and KGB-1(JNK). ..
Xu A, Shi G, Liu F, Ge B. Caenorhabditis elegans mom-4 is required for the activation of the p38 MAPK signaling pathway in the response to Pseudomonas aeruginosa infection. Protein Cell. 2013;4:53-61 pubmed publisher
..elegans is required for P. aeruginosa resistance, but not through the regulation of DLK-1. In summary, our results indicate that different upstream MAPKKKs or MAPKKs regulate the activation of PMK-1 in response to P. Aeruginosa. ..
Hammarlund M, Nix P, Hauth L, Jorgensen E, Bastiani M. Axon regeneration requires a conserved MAP kinase pathway. Science. 2009;323:802-6 pubmed publisher
..We conclude that after axon injury, activation of this MAP kinase cascade is required to switch the mature neuron from an aplastic state to a state capable of growth. ..
Yan D, Wu Z, Chisholm A, Jin Y. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell. 2009;138:1005-18 pubmed publisher
..Our findings identify the DLK-1 pathway as a regulator of mRNA stability in synapse formation and maintenance and also in adult axon regeneration. ..
Hung W, Hwang C, Gao S, Liao E, Chitturi J, Wang Y, et al
. Attenuation of insulin signalling contributes to FSN-1-mediated regulation of synapse development. EMBO J. 2013;32:1745-60 pubmed publisher
..We propose that FSN-1 may negatively regulate insulin/IGF signalling, in part, through EGL-3-dependent insulin-like ligand processing. ..