Gene Symbol: mig-5
Description: Segment polarity protein dishevelled homolog mig-5
Alias: Segment polarity protein dishevelled homolog mig-5
Species: Caenorhabditis elegans
Walston T, Tuskey C, Edgar L, Hawkins N, Ellis G, Bowerman B, et al
. Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C. elegans embryos. Dev Cell. 2004;7:831-41 pubmed
Walston T, Guo C, Proenca R, Wu M, Herman M, Hardin J, et al
. mig-5/Dsh controls cell fate determination and cell migration in C. elegans. Dev Biol. 2006;298:485-97 pubmed
..These defects demonstrate that MIG-5 is essential in determining proper cell fate and cell migration throughout C. elegans development. ..
Korswagen H, Coudreuse D, Betist M, van de Water S, Zivkovic D, Clevers H. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev. 2002;16:1291-302 pubmed
..We conclude that a highly divergent destruction complex consisting of PRY-1, SGG-1, and APR-1 regulates BAR-1/beta-catenin signaling in C. elegans. ..
Phillips B, Kidd A, King R, Hardin J, Kimble J. Reciprocal asymmetry of SYS-1/beta-catenin and POP-1/TCF controls asymmetric divisions in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2007;104:3231-6 pubmed
..We suggest a two-pronged pathway for control of SYS-1:POP-1, which can robustly accomplish differential gene expression in daughters of an asymmetric cell division. ..
Oosterveen T, Coudreuse D, Yang P, Fraser E, Bergsma J, Dale T, et al
. Two functionally distinct Axin-like proteins regulate canonical Wnt signaling in C. elegans. Dev Biol. 2007;308:438-48 pubmed
..We conclude that Axin function in C. elegans is divided over two different Axin orthologs that have specific functions in negatively regulating canonical Wnt signaling. ..
Bei Y, Hogan J, Berkowitz L, Soto M, Rocheleau C, Pang K, et al
. SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. Dev Cell. 2002;3:113-25 pubmed
..Our findings suggest that Wnt and Src signaling function in parallel to control developmental outcomes within a single responding cell. ..
Hawkins N, Ellis G, Bowerman B, Garriga G. MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions. Dev Biol. 2005;284:246-59 pubmed
..Although all neurons in C. elegans are produced by an invariant pattern of cell divisions, our results indicate that cell signaling may contribute to asymmetric neuroblast division during embryogenesis. ..
Wu M, Herman M. A novel noncanonical Wnt pathway is involved in the regulation of the asymmetric B cell division in C. elegans. Dev Biol. 2006;293:316-29 pubmed
..We conclude that a noncanonical Wnt pathway, which is different from other Wnt pathways in C. elegans, regulates B cell polarity. ..
King R, Maiden S, Hawkins N, Kidd A, Kimble J, Hardin J, et al
. The N- or C-terminal domains of DSH-2 can activate the C. elegans Wnt/beta-catenin asymmetry pathway. Dev Biol. 2009;328:234-44 pubmed publisher
..These results indicate that either the DIX or DEP domain of DSH-2 is capable of activating the Wnt/beta-catenin asymmetry pathway and regulating anterior-posterior fate decisions required for proper morphogenesis. ..