Gene Symbol: mig-10
Description: Abnormal cell migration protein 10
Alias: Abnormal cell migration protein 10
Species: Caenorhabditis elegans

Top Publications

  1. Quinn C, Pfeil D, Chen E, Stovall E, Harden M, Gavin M, et al. UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin. Curr Biol. 2006;16:845-53 pubmed
    ..The attractive and repulsive guidance cues orient MIG-10-dependant axon outgrowth to cause a directional response. ..
  2. Chang C, Adler C, Krause M, Clark S, Gertler F, Tessier Lavigne M, et al. MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Curr Biol. 2006;16:854-62 pubmed
    ..mig-10 and age-1 lipid signaling promote axon outgrowth; unc-34 and to a lesser extent mig-10 promote filopodia formation. Surprisingly, filopodia are largely dispensable for accurate axon guidance. ..
  3. Manser J, Wood W. Mutations affecting embryonic cell migrations in Caenorhabditis elegans. Dev Genet. 1990;11:49-64 pubmed
    ..The possible nature of the mutant defects and possible roles of these four loci in cell migration are discussed. ..
  4. Quinn C, Pfeil D, Wadsworth W. CED-10/Rac1 mediates axon guidance by regulating the asymmetric distribution of MIG-10/lamellipodin. Curr Biol. 2008;18:808-13 pubmed publisher
    ..We propose that the interaction between activated CED-10/Rac1 and MIG-10/lamellipodin triggers local cytoskeletal assembly and polarizes outgrowth activity in response to UNC-6/netrin. ..
  5. Stavoe A, Nelson J, Martinez Velazquez L, Klein M, Samuel A, COLON RAMOS D. Synaptic vesicle clustering requires a distinct MIG-10/Lamellipodin isoform and ABI-1 downstream from Netrin. Genes Dev. 2012;26:2206-21 pubmed publisher
  6. Wang L, Shen W, Lei S, MATUS D, Sherwood D, Wang Z. MIG-10 (Lamellipodin) stabilizes invading cell adhesion to basement membrane and is a negative transcriptional target of EGL-43 in C. elegans. Biochem Biophys Res Commun. 2014;452:328-33 pubmed publisher
    ..Thus, we provide new insight into MIG-10's function and its complex transcriptional regulation during cell invasive behavior. ..
  7. Gabel C, Antoine F, Antonie F, Chuang C, Samuel A, Chang C. Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans. Development. 2008;135:1129-36 pubmed publisher
    ..Thus, C. elegans may be used as a genetic system to characterize novel cellular and molecular mechanisms underlying adult-stage nervous system regeneration. ..
  8. McShea M, Schmidt K, Dubuke M, Baldiga C, Sullender M, Reis A, et al. Abelson interactor-1 (ABI-1) interacts with MRL adaptor protein MIG-10 and is required in guided cell migrations and process outgrowth in C. elegans. Dev Biol. 2013;373:1-13 pubmed publisher
    ..Taken together, our results suggest that MIG-10, UNC-53, and ABI-1 act sequentially to mediate excretory cell process outgrowth...
  9. Desai C, Garriga G, McIntire S, Horvitz H. A genetic pathway for the development of the Caenorhabditis elegans HSN motor neurons. Nature. 1988;336:638-46 pubmed
    ..Nearly all are pleiotropic, revealing that the genes specifying HSN development also function in the development of other cell types. ..

More Information


  1. Ma L, Gao X, Luo J, Huang L, Teng Y, Horvitz H. The Caenorhabditis elegans gene mfap-1 encodes a nuclear protein that affects alternative splicing. PLoS Genet. 2012;8:e1002827 pubmed publisher
    ..Using a yeast two-hybrid screen, we isolated splicing factors as potential MFAP-1 interactors. Our studies indicate that C. elegans mfap-1 encodes a splicing factor that can affect alternative splicing. ..
  2. Wang Z, Chi Q, Sherwood D. MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans. Development. 2014;141:1342-53 pubmed publisher
    ..These studies indicate that MIG-10 has distinct functions from UNC-40 signaling in cell invasion, and demonstrate that integrin coordinates invasion by localizing these molecules to the cell-basement membrane interface. ..
  3. Stavoe A, Col n Ramos D. Netrin instructs synaptic vesicle clustering through Rac GTPase, MIG-10, and the actin cytoskeleton. J Cell Biol. 2012;197:75-88 pubmed publisher
    ..Our data indicate that signaling modules known to organize the actin cytoskeleton during guidance can be co-opted to instruct synaptic vesicle clustering...
  4. Xu Y, Quinn C. MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways. PLoS Genet. 2012;8:e1003054 pubmed publisher
    ..Together, these observations suggest that MIG-10 interacts with ABI-1 and WVE-1 to mediate the UNC-6 and SLT-1 guidance pathways...