Gene Symbol: mex-5
Description: Zinc finger protein mex-5
Alias: Zinc finger protein mex-5
Species: Caenorhabditis elegans
Hanazawa M, Mochii M, Ueno N, Kohara Y, Iino Y. Use of cDNA subtraction and RNA interference screens in combination reveals genes required for germ-line development in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2001;98:8686-91 pubmed
..These results demonstrate the efficacy of the screening strategy using the EST library combined with the RNAi technique in C. elegans. ..
Lin R. A gain-of-function mutation in oma-1, a C. elegans gene required for oocyte maturation, results in delayed degradation of maternal proteins and embryonic lethality. Dev Biol. 2003;258:226-39 pubmed
..These observations suggest that oma-1, in addition to its role in oocyte maturation, contributes to early embryonic development by regulating the temporal degradation of maternal proteins in early C. elegans embryos. ..
Pagano J, Farley B, McCoig L, Ryder S. Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5. J Biol Chem. 2007;282:8883-94 pubmed
..This residue is variable in nematode TZF proteins, but is invariant in other metazoans. Therefore, the divergence of TZF proteins and their critical role in early development is likely a nematode-specific adaptation. ..
Tenlen J, Molk J, London N, Page B, Priess J. MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation. Development. 2008;135:3665-75 pubmed publisher
..PAR-1 and PAR-4 kinase activities are required for the phosphorylation of S458, providing a link between PAR polarity proteins and the cytoplasmic asymmetry of MEX-5. ..
Daniels B, Dobrowsky T, Perkins E, Sun S, Wirtz D. MEX-5 enrichment in the C. elegans early embryo mediated by differential diffusion. Development. 2010;137:2579-85 pubmed publisher
..This work extends the scope of reaction/diffusion models to include not only germline morphogens, but also somatic determinants. ..
Schubert C, Lin R, de Vries C, Plasterk R, Priess J. MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryos. Mol Cell. 2000;5:671-82 pubmed
..Ectopic expression of MEX-5 is sufficient to inhibit the expression of germline proteins, suggesting that MEX-5 functions to inhibit anterior expression of the germline proteins. ..
Nishi Y, Rogers E, Robertson S, Lin R. Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6. Development. 2008;135:687-97 pubmed publisher
..Our results provide a mechanism by which MEX-5 and MEX-6 function is temporally regulated during the crucial oocyte-to-embryo transition. ..
Cuenca A, Schetter A, Aceto D, Kemphues K, Seydoux G. Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phases. Development. 2003;130:1255-65 pubmed
..These findings provide a model for how PAR and MEX proteins convert a transient asymmetry into a stably polarized axis. ..
Griffin E, Odde D, Seydoux G. Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycle. Cell. 2011;146:955-68 pubmed publisher
..The principles demonstrated here apply to any spatially segregated modification cycle that affects protein diffusion and do not require protein synthesis or degradation...