Gene Symbol: mex-3
Description: Muscle EXcess
Alias: Muscle EXcess
Species: Caenorhabditis elegans
Draper B, Mello C, Bowerman B, Hardin J, Priess J. MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryos. Cell. 1996;87:205-16 pubmed
..We propose that MEX-3 contributes to anterior-posterior asymmetry by regulating one or more mRNAs involved in specifying the fate of the posterior blastomere. ..
Ciosk R, DePalma M, Priess J. ATX-2, the C. elegans ortholog of ataxin 2, functions in translational regulation in the germline. Development. 2004;131:4831-41 pubmed
..Together, our results suggest that ATX-2 functions in translational regulation that is mediated by GLD-1 and MEX-3 proteins. ..
Pagano J, Farley B, Essien K, Ryder S. RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3. Proc Natl Acad Sci U S A. 2009;106:20252-7 pubmed publisher
..Based on this work, we identify several candidate MEX-3 targets that help explain its dual role in regulating germline stem cell totipotency and embryonic cell fate specification. ..
Ciosk R, DePalma M, Priess J. Translational regulators maintain totipotency in the Caenorhabditis elegans germline. Science. 2006;311:851-3 pubmed
Oldenbroek M, Robertson S, Guven Ozkan T, Spike C, Greenstein D, Lin R. Regulation of maternal Wnt mRNA translation in C. elegans embryos. Development. 2013;140:4614-23 pubmed publisher
..We propose that the 3'UTR of maternal mRNAs contains a combinatorial code that determines the topography of associated RBPs, integrating positive and negative translational inputs. ..
Pagano J, Farley B, McCoig L, Ryder S. Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5. J Biol Chem. 2007;282:8883-94 pubmed
..This residue is variable in nematode TZF proteins, but is invariant in other metazoans. Therefore, the divergence of TZF proteins and their critical role in early development is likely a nematode-specific adaptation. ..
Huang N, Hunter C. The RNA binding protein MEX-3 retains asymmetric activity in the early Caenorhabditis elegans embryo in the absence of asymmetric protein localization. Gene. 2015;554:160-73 pubmed publisher
..These results indicate that mex-3 activity is regulated at multiple levels, leading to rapid and robust regulation in the quickly developing early embryo. ..
Hunter C, Kenyon C. Spatial and temporal controls target pal-1 blastomere-specification activity to a single blastomere lineage in C. elegans embryos. Cell. 1996;87:217-26 pubmed
Huang N, Mootz D, Walhout A, Vidal M, Hunter C. MEX-3 interacting proteins link cell polarity to asymmetric gene expression in Caenorhabditis elegans. Development. 2002;129:747-59 pubmed
..We propose that MEX-6 and SPN-4 act with MEX-3 to translate the temporal and spatial information provided by the early acting par genes into the asymmetric expression of the cell fate determinant PAL-1. ..