Gene Symbol: mes-3
Description: Maternal Effect Sterile;Polycomb protein mes-3
Alias: Maternal Effect Sterile;Polycomb protein mes-3
Species: Caenorhabditis elegans
Capowski E, Martin P, Garvin C, Strome S. Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans. Genetics. 1991;129:1061-72 pubmed
..This is in contrast to grandchildless mutations in Drosophila melanogaster, all of which disrupt germ granules and affect abdominal as well as germ-line development...
Xu L, Fong Y, Strome S. The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryos. Proc Natl Acad Sci U S A. 2001;98:5061-6 pubmed
..Our results suggest that the two C. elegans Polycomb group homologs (MES-2 and MES-6) associate with a novel partner (MES-3) to regulate germ-line development in C. elegans. ..
Dudley N, Labbé J, Goldstein B. Using RNA interference to identify genes required for RNA interference. Proc Natl Acad Sci U S A. 2002;99:4191-6 pubmed
..The finding that genes predicted to encode proteins that associate with chromatin are involved in RNAi in C. elegans raises the possibility that chromatin may play a role in RNAi in animals, as it does in plants. ..
Ross J, Zarkower D. Polycomb group regulation of Hox gene expression in C. elegans. Dev Cell. 2003;4:891-901 pubmed
..Thus, as in Drosophila, vertebrates, and plants, C. elegans PcG proteins regulate key developmental patterning genes to establish positional identity. ..
Bender L, Cao R, Zhang Y, Strome S. The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegans. Curr Biol. 2004;14:1639-43 pubmed
..Our results contribute to understanding the composition and roles of E(Z)/MES-2 complexes across species...
Xu L, Paulsen J, Yoo Y, Goodwin E, Strome S. Caenorhabditis elegans MES-3 is a target of GLD-1 and functions epigenetically in germline development. Genetics. 2001;159:1007-17 pubmed
..We propose that MES-3 acts epigenetically to induce a germline state that is inherited through both meiosis and mitosis and that is essential for survival of the germline...
Pires daSilva A, Sommer R. Finally, worm polycomb-like genes meet Hox regulation. Dev Cell. 2003;4:770-2 pubmed
..elegans. However, sequence comparison indicates that these genes may not be homologous to the fly Polycomb genes, suggesting that independent gene recruitment occurred during nematode evolution. ..