Gene Symbol: mes-1
Description: Protein mes-1
Alias: Protein mes-1
Species: Caenorhabditis elegans

Top Publications

  1. Bei Y, Hogan J, Berkowitz L, Soto M, Rocheleau C, Pang K, et al. SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryos. Dev Cell. 2002;3:113-25 pubmed
    ..Our findings suggest that Wnt and Src signaling function in parallel to control developmental outcomes within a single responding cell. ..
  2. Tsou M, Hayashi A, Rose L. LET-99 opposes Galpha/GPR signaling to generate asymmetry for spindle positioning in response to PAR and MES-1/SRC-1 signaling. Development. 2003;130:5717-30 pubmed
    ..These results provide insight into how polarity cues are transmitted into specific spindle positions in both extrinsic and intrinsic pathways of asymmetric cell division. ..
  3. Wu Q, Cao X, Yan D, Wang D, Aballay A. Genetic Screen Reveals Link between the Maternal Effect Sterile Gene mes-1 and Pseudomonas aeruginosa-induced Neurodegeneration in Caenorhabditis elegans. J Biol Chem. 2015;290:29231-9 pubmed publisher
    ..Thus, our results demonstrate that P. aeruginosa infection results in neurodegeneration phenotypes in C. elegans that are controlled by the germ line in a cell-nonautonomous manner. ..
  4. Berkowitz L, Strome S. MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cells. Development. 2000;127:4419-31 pubmed
    ..Our results suggest that MES-1 directly positions the developing mitotic spindle and its associated P granules within P(2) and P(3), or provides an orientation signal for P(2)- and P(3)-specific events. ..