Gene Symbol: mel-26
Description: Protein maternal effect lethal 26;hypothetical protein
Alias: Protein maternal effect lethal 26;hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Pintard L, Willis J, Willems A, Johnson J, Srayko M, Kurz T, et al. The BTB protein MEL-26 is a substrate-specific adaptor of the CUL-3 ubiquitin-ligase. Nature. 2003;425:311-6 pubmed
    ..Our results suggest that BTB-containing proteins may generally function as substrate-specific adaptors in Cul3-based E3-ubiquitin ligases. ..
  2. Xu L, Wei Y, Reboul J, Vaglio P, Shin T, Vidal M, et al. BTB proteins are substrate-specific adaptors in an SCF-like modular ubiquitin ligase containing CUL-3. Nature. 2003;425:316-21 pubmed
    ..elegans CUL-3. Biochemical studies using the BTB protein MEL-26 and its genetic target MEI-1 (refs 12, 13) indicate that BTB proteins merge the functional properties of Skp1 and F-box proteins into a single polypeptide. ..
  3. Luke Glaser S, Roy M, Larsen B, Le Bihan T, Metalnikov P, Tyers M, et al. CIF-1, a shared subunit of the COP9/signalosome and eukaryotic initiation factor 3 complexes, regulates MEL-26 levels in the Caenorhabditis elegans embryo. Mol Cell Biol. 2007;27:4526-40 pubmed
    ..F and inactivation of cif-1 impairs translation in vivo. Taken together, our results indicate that CIF-1 is a shared subunit of the CSN and eIF3 complexes and may therefore link protein translation and degradation. ..
  4. Luke Glaser S, Pintard L, Tyers M, Peter M. The AAA-ATPase FIGL-1 controls mitotic progression, and its levels are regulated by the CUL-3MEL-26 E3 ligase in the C. elegans germ line. J Cell Sci. 2007;120:3179-87 pubmed
    ..We conclude that degradation of FIGL-1 by the CUL-3MEL-26 E3 ligase spatially restricts FIGL-1 function to mitotic cells, where it is required for correct progression through mitosis. ..
  5. Lu C, Mains P. The C. elegans anaphase promoting complex and MBK-2/DYRK kinase act redundantly with CUL-3/MEL-26 ubiquitin ligase to degrade MEI-1 microtubule-severing activity after meiosis. Dev Biol. 2007;302:438-47 pubmed
    ..We propose that mbk-2 and apc couple the initial phase of MEI-1 degradation to meiotic exit, after which MEL-26 completes MEI-1 degradation. ..
  6. Han X, Gomes J, Birmingham C, Pintard L, Sugimoto A, Mains P. The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo. Genetics. 2009;181:933-43 pubmed publisher
    ..The redundant regulatory pathways likely contribute in different ways to the rapid and precise post-meiotic inactivation of MEI-1 microtubule-severing activity. ..
  7. Johnson J, Lu C, Raharjo E, McNally K, McNally F, Mains P. Levels of the ubiquitin ligase substrate adaptor MEL-26 are inversely correlated with MEI-1/katanin microtubule-severing activity during both meiosis and mitosis. Dev Biol. 2009;330:349-57 pubmed publisher
    ..We also show that MEI-1 is the only essential target for MEL-26, and possibly for the E3 ubiquitin ligase CUL-3, but the upstream ubiquitin ligase activating enzyme RFL-1 has additional essential targets. ..
  8. Luke Glaser S, Pintard L, Lu C, Mains P, Peter M. The BTB protein MEL-26 promotes cytokinesis in C. elegans by a CUL-3-independent mechanism. Curr Biol. 2005;15:1605-15 pubmed
    ..Our results suggest that MEL-26 not only acts as a substrate-specific adaptor within the MEL-26/CUL-3 complex, but also promotes cytokinesis by a CUL-3- and microtubule-independent mechanism. ..
  9. Figueroa P, Gusmaroli G, Serino G, Habashi J, Ma L, Shen Y, et al. Arabidopsis has two redundant Cullin3 proteins that are essential for embryo development and that interact with RBX1 and BTB proteins to form multisubunit E3 ubiquitin ligase complexes in vivo. Plant Cell. 2005;17:1180-95 pubmed

More Information


  1. Wilson K, Qadota H, Mains P, Benian G. UNC-89 (obscurin) binds to MEL-26, a BTB-domain protein, and affects the function of MEI-1 (katanin) in striated muscle of Caenorhabditis elegans. Mol Biol Cell. 2012;23:2623-34 pubmed publisher
    ..The level of MEI-1 protein is reduced in an unc-89 mutant, suggesting that the normal role of UNC-89 is to inhibit the CUL-3/MEL-26 complex toward MEI-1. ..
  2. Li Y, Zhang Q, Wei Q, Zhang Y, Ling K, Hu J. SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors. J Cell Biol. 2012;199:589-98 pubmed publisher
    ..Our data reveal a novel but conserved role for the SUMOylation modification of ciliary small GTPase ARL13B in specifically regulating the proper ciliary targeting of various sensory receptors. ..
  3. Gomes J, Tavernier N, Richaudeau B, Formstecher E, Boulin T, Mains P, et al. Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. J Cell Biol. 2013;202:431-9 pubmed publisher