Gene Symbol: mek-2
Description: Dual specificity mitogen-activated protein kinase kinase mek-2
Alias: Dual specificity mitogen-activated protein kinase kinase mek-2
Species: Caenorhabditis elegans

Top Publications

  1. Stewart S, Sundaram M, Zhang Y, Lee J, Han M, Guan K. Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. Mol Cell Biol. 1999;19:5523-34 pubmed
    ..Together, these results suggest that KSR may act as a scaffolding protein for the Ras-mitogen-activated protein kinase pathway. ..
  2. Nicholas H, Hodgkin J. The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans. Curr Biol. 2004;14:1256-61 pubmed
    ..elegans from severe constipation, which would otherwise arrest development and cause sterility. Involvement in pathogen defense represents a new role for ERK MAP kinase signaling in this organism. ..
  3. Okuyama T, Inoue H, Ookuma S, Satoh T, Kano K, Honjoh S, et al. The ERK-MAPK pathway regulates longevity through SKN-1 and insulin-like signaling in Caenorhabditis elegans. J Biol Chem. 2010;285:30274-81 pubmed publisher
    ..Our findings thus identify a novel ERK-MAPK-mediated signaling pathway that promotes longevity. ..
  4. Hsu V, Zobel C, Lambie E, Schedl T, Kornfeld K. Caenorhabditis elegans lin-45 raf is essential for larval viability, fertility and the induction of vulval cell fates. Genetics. 2002;160:481-92 pubmed
    ..elegans development. ..
  5. Mizuno T, Fujiki K, Sasakawa A, Hisamoto N, Matsumoto K. Role of the Caenorhabditis elegans Shc adaptor protein in the c-Jun N-terminal kinase signaling pathway. Mol Cell Biol. 2008;28:7041-9 pubmed publisher
    ..These results suggest that SHC-1 acts as a scaffold to link MAPKKK to MAPKK activation in the KGB-1 MAPK signal transduction pathway. ..
  6. Falin R, Miyazaki H, Strange K. C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling. Am J Physiol Cell Physiol. 2011;300:C624-35 pubmed publisher
    ..We postulate that MEK-2/MPK-1 functions upstream from GCK-3 to regulate its activity during cell volume and meiotic cell cycle changes. ..
  7. Etheridge T, Oczypok E, Lehmann S, Fields B, Shephard F, Jacobson L, et al. Calpains mediate integrin attachment complex maintenance of adult muscle in Caenorhabditis elegans. PLoS Genet. 2012;8:e1002471 pubmed publisher
    ..Since C. elegans lacks satellite cells, this mechanism is intrinsic to the muscles and raises the question if such a mechanism also exists in higher metazoans. ..
  8. Wu Y, Han M, Guan K. MEK-2, a Caenorhabditis elegans MAP kinase kinase, functions in Ras-mediated vulval induction and other developmental events. Genes Dev. 1995;9:742-55 pubmed
    ..Our results demonstrate that mek-2 acts between lin-45 raf and sur-1/mpk-1 in a signal transduction pathway used in the control of vulval differentiation and other developmental events. ..