Gene Symbol: mei-2
Description: Meiotic spindle formation protein 2
Alias: Meiotic spindle formation protein 2
Species: Caenorhabditis elegans
Mains P, Kemphues K, Sprunger S, Sulston I, Wood W. Mutations affecting the meiotic and mitotic divisions of the early Caenorhabditis elegans embryo. Genetics. 1990;126:593-605 pubmed
..The products of the four genes mei-1, mei-2, zyg-9 and mel-26 could be responsible for some of the specialized features that distinguish the meiotic from the mitotic divisions in the one-cell embryo. ..
Srayko M, Buster D, Bazirgan O, McNally F, Mains P. MEI-1/MEI-2 katanin-like microtubule severing activity is required for Caenorhabditis elegans meiosis. Genes Dev. 2000;14:1072-84 pubmed
..These data lead us to conclude that MEI-1/MEI-2 microtubule-severing activity is required for meiotic spindle organization in C. elegans. ..
Pellettieri J, Reinke V, Kim S, Seydoux G. Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegans. Dev Cell. 2003;5:451-62 pubmed
..We propose that MBK-2 functions as a temporal regulator of protein stability, and that coordinate activation of maternal protein degradation is one of the mechanisms that drives the transition from symmetric egg to patterned embryo. ..
Han X, Gomes J, Birmingham C, Pintard L, Sugimoto A, Mains P. The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo. Genetics. 2009;181:933-43 pubmed publisher
..The redundant regulatory pathways likely contribute in different ways to the rapid and precise post-meiotic inactivation of MEI-1 microtubule-severing activity. ..
McNally K, Berg E, Cortes D, Hernández V, Mains P, McNally F. Katanin maintains meiotic metaphase chromosome alignment and spindle structure in vivo and has multiple effects on microtubules in vitro. Mol Biol Cell. 2014;25:1037-49 pubmed publisher
..These activities could promote parallel/antiparallel microtubule organization in meiotic spindles. ..