Gene Symbol: mdf-1
Description: MAD (yeast Mitosis arrest DeFicient) related
Alias: MAD (yeast Mitosis arrest DeFicient) related
Species: Caenorhabditis elegans
Tarailo M, Kitagawa R, Rose A. Suppressors of spindle checkpoint defect (such) mutants identify new mdf-1/MAD1 interactors in Caenorhabditis elegans. Genetics. 2007;175:1665-79 pubmed
..elegans. The such-1/APC5-like mutation, h1960, significantly delays anaphase onset both in germline and in early embryonic cells. ..
Watanabe S, Yamamoto T, Kitagawa R. Spindle assembly checkpoint gene mdf-1 regulates germ cell proliferation in response to nutrition signals in C. elegans. EMBO J. 2008;27:1085-96 pubmed publisher
Yamamoto T, Watanabe S, Essex A, Kitagawa R. SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans. J Cell Biol. 2008;183:187-94 pubmed publisher
..In addition, SPDL-1 coimmunoprecipitates with MDF-1/MAD1 in vivo. These results suggest that SPDL-1 functions in a kinetochore receptor of MDF-1/MAD1 to induce SAC function. ..
Buttner E, Gil Krzewska A, Rajpurohit A, Hunter C. Progression from mitotic catastrophe to germ cell death in Caenorhabditis elegans lis-1 mutants requires the spindle checkpoint. Dev Biol. 2007;305:397-410 pubmed
..These results suggest that apoptosis may contribute to the cell-sparse pathology of lissencephaly. ..
Tarailo Graovac M, Wong T, Qin Z, Flibotte S, Taylor J, Moerman D, et al
. Spectrum of variations in dog-1/FANCJ and mdf-1/MAD1 defective Caenorhabditis elegans strains after long-term propagation. BMC Genomics. 2015;16:210 pubmed publisher
..elegans' genome after long-term propagation in the absence of DOG-1 and MDF-1. We showed that DNA sequences, with G4-forming potential, are vulnerable to deletion-formation in this genetic background. ..
Lawrence K, Chau T, Engebrecht J. DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity. PLoS Genet. 2015;11:e1005150 pubmed publisher
..We also show that replication perturbations result in relocalization of MAD1/MAD2 in human cells, suggesting that the role of SAC in DNA repair is conserved. ..
Tarailo Graovac M, Wang J, Tu D, Baillie D, Rose A, Chen N. Duplication of cyb-3 (cyclin B3) suppresses sterility in the absence of mdf-1/MAD1 spindle assembly checkpoint component in Caenorhabditis elegans. Cell Cycle. 2010;9:4858-65 pubmed
..Importantly, we show here, for the first time, that doubling the CYB-3 (Cyclin B3) dosage suppresses sterility in the absence of the essential spindle assembly checkpoint component MDF-1 without causing a delay in the onset of anaphase. ..
Ródenas E, González Aguilera C, Ayuso C, Askjaer P. Dissection of the NUP107 nuclear pore subcomplex reveals a novel interaction with spindle assembly checkpoint protein MAD1 in Caenorhabditis elegans. Mol Biol Cell. 2012;23:930-44 pubmed publisher
..Thus our results strengthen the emerging connection between nuclear pore proteins and chromosome segregation. ..
Moyle M, Kim T, Hattersley N, Espeut J, Cheerambathur D, Oegema K, et al
. A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint. J Cell Biol. 2014;204:647-57 pubmed publisher
..These results delineate an interaction between BUB-1 and MAD-1 that targets MAD-1-MAD-2 complexes to kinetochores and is essential for spindle checkpoint signaling. ..