mbk-2

Summary

Gene Symbol: mbk-2
Description: Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2;MiniBrain Kinase (Drosophila) homolog
Alias: Dual specificity tyrosine-phosphorylation-regulated kinase mbk-2;MiniBrain Kinase (Drosophila) homolog
Species: Caenorhabditis elegans

Top Publications

  1. Pellettieri J, Reinke V, Kim S, Seydoux G. Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegans. Dev Cell. 2003;5:451-62 pubmed
    ..We propose that MBK-2 functions as a temporal regulator of protein stability, and that coordinate activation of maternal protein degradation is one of the mechanisms that drives the transition from symmetric egg to patterned embryo. ..
  2. Quintin S, Mains P, Zinke A, Hyman A. The mbk-2 kinase is required for inactivation of MEI-1/katanin in the one-cell Caenorhabditis elegans embryo. EMBO Rep. 2003;4:1175-81 pubmed
    ..We propose that mbk-2 potentiates the degradation of MEI-1 and other proteins, possibly via direct phosphorylation. ..
  3. Stitzel M, Pellettieri J, Seydoux G. The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic Maturation. Curr Biol. 2006;16:56-62 pubmed
    ..Our findings suggest that regulators of meiotic M phase activate a remodeling program, independently of fertilization, to prepare eggs for embryogenesis. ..
  4. Cheng K, Klancer R, Singson A, Seydoux G. Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition. Cell. 2009;139:560-72 pubmed publisher
    ..Our findings link cell-cycle progression to MBK-2/DYRK activation and the oocyte-to-embryo transition. ..
  5. Wang J, Smith J, Chen B, Schmidt H, Rasoloson D, Paix A, et al. Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. elife. 2014;3:e04591 pubmed publisher
    ..We conclude that, despite their liquid-like behavior, P granules are non-homogeneous structures whose assembly in embryos is regulated by phosphorylation. ..
  6. Raich W, Moorman C, Lacefield C, Lehrer J, Bartsch D, Plasterk R, et al. Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A. Genetics. 2003;163:571-80 pubmed
    ..Our results suggest that increased gene dosage of human DYRK1A in trisomy 21 may disrupt the function of fully differentiated neurons and that this disruption is reversible. ..
  7. Pang K, Ishidate T, Nakamura K, Shirayama M, Trzepacz C, Schubert C, et al. The minibrain kinase homolog, mbk-2, is required for spindle positioning and asymmetric cell division in early C. elegans embryos. Dev Biol. 2004;265:127-39 pubmed
    ..These findings in conjunction with work from Schizosaccharomyces pombe indicate a possible conserved role for Dyrk family kinases in the regulation of spindle placement during cell division. ..
  8. Shirayama M, Soto M, Ishidate T, Kim S, Nakamura K, Bei Y, et al. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Curr Biol. 2006;16:47-55 pubmed
  9. Stitzel M, Cheng K, Seydoux G. Regulation of MBK-2/Dyrk kinase by dynamic cortical anchoring during the oocyte-to-zygote transition. Curr Biol. 2007;17:1545-54 pubmed
    ..In C. elegans, degradation of the oocyte protein MEI-1 depends on MBK-2, a kinase that phosphorylates MEI-1 shortly after fertilization during the second meiotic division...

More Information

Publications13

  1. Nishi Y, Rogers E, Robertson S, Lin R. Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6. Development. 2008;135:687-97 pubmed publisher
    ..Our results provide a mechanism by which MEX-5 and MEX-6 function is temporally regulated during the crucial oocyte-to-embryo transition. ..
  2. Guven Ozkan T, Robertson S, Nishi Y, Lin R. zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repression. Development. 2010;137:3373-82 pubmed publisher
  3. Nishi Y, Lin R. DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegans. Dev Biol. 2005;288:139-49 pubmed
    ..elegans. ..
  4. Han X, Gomes J, Birmingham C, Pintard L, Sugimoto A, Mains P. The role of protein phosphatase 4 in regulating microtubule severing in the Caenorhabditis elegans embryo. Genetics. 2009;181:933-43 pubmed publisher
    ..The redundant regulatory pathways likely contribute in different ways to the rapid and precise post-meiotic inactivation of MEI-1 microtubule-severing activity. ..