Gene Symbol: mat 3
Description: Cell division cycle protein 23 homolog
Alias: Cell division cycle protein 23 homolog
Species: Caenorhabditis elegans
Rappleye C, Tagawa A, Lyczak R, Bowerman B, Aroian R. The anaphase-promoting complex and separin are required for embryonic anterior-posterior axis formation. Dev Cell. 2002;2:195-206 pubmed
..We propose that the APC/separin pathway promotes close association of the centrosome with the cortex, which in turn excludes PAR-3 from the posterior pole early in a-p axis formation. ..
Davis E, Wille L, Chestnut B, Sadler P, Shakes D, Golden A. Multiple subunits of the Caenorhabditis elegans anaphase-promoting complex are required for chromosome segregation during meiosis I. Genetics. 2002;160:805-13 pubmed
..Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion. ..
Zhang Y, Lindblom T, Chang A, Sudol M, Sluder A, Golemis E. Evidence that dim1 associates with proteins involved in pre-mRNA splicing, and delineation of residues essential for dim1 interactions with hnRNP F and Npw38/PQBP-1. Gene. 2000;257:33-43 pubmed
..These results parallel the arrest phenotypes associated with global disruption of zygotic gene expression, suggesting that Dim1 proteins maintain an essential function in gene expression in higher eukaryotes. ..
Garbe D, Doto J, Sundaram M. Caenorhabditis elegans lin-35/Rb, efl-1/E2F and other synthetic multivulva genes negatively regulate the anaphase-promoting complex gene mat-3/APC8. Genetics. 2004;167:663-72 pubmed
..Loss-of-function alleles of lin-35/Rb and other SynMuv B genes suppress mat-3(ku233) defects by restoring mat-3 mRNA to wild-type levels. Therefore, Rb/E2F complexes appear to repress mat-3 expression. ..
Sieburth D, Ch ng Q, Dybbs M, Tavazoie M, Kennedy S, Wang D, et al
. Systematic analysis of genes required for synapse structure and function. Nature. 2005;436:510-7 pubmed
..Twenty-four genes encoded proteins that were localized to presynaptic specializations. Loss-of-function mutations in 12 genes caused defects in presynaptic structure...
Yamamoto T, Watanabe S, Essex A, Kitagawa R. SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans. J Cell Biol. 2008;183:187-94 pubmed publisher
..In addition, SPDL-1 coimmunoprecipitates with MDF-1/MAD1 in vivo. These results suggest that SPDL-1 functions in a kinetochore receptor of MDF-1/MAD1 to induce SAC function. ..