Research Topics

Genomes and Genes

Gene Symbol: mak-2

Description: MAP kinase-activated protein kinase mak-2

Alias: MAP kinase-activated protein kinase mak-2

Species: Caenorhabditis elegans

Bell R, Hubbard A, Chettier R, Chen D, Miller J, Kapahi P, et al. A human protein interaction network shows conservation of aging processes between human and invertebrate species. PLoS Genet. 2009;5:e1000414 pubmed publisher

..They also indicate that the longevity protein interaction network presented here is enriched for novel conserved longevity proteins. ..
Yan D, Wu Z, Chisholm A, Jin Y. The DLK-1 kinase promotes mRNA stability and local translation in C. elegans synapses and axon regeneration. Cell. 2009;138:1005-18 pubmed publisher

..Our findings identify the DLK-1 pathway as a regulator of mRNA stability in synapse formation and maintenance and also in adult axon regeneration. ..
Nix P, Hisamoto N, Matsumoto K, Bastiani M. Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways. Proc Natl Acad Sci U S A. 2011;108:10738-43 pubmed publisher

..These two MAPKs are coregulated by the E3 ubiquitin ligase RPM-1(Phr1) via targeted degradation of the MAPKKKs DLK-1 and MLK-1 and by the MAPK phosphatase VHP-1(MKP7), which negatively regulates both PMK-3(p38) and KGB-1(JNK). ..
Matsunaga Y, Qadota H, Furukawa M, Choe H, Benian G. Twitchin kinase interacts with MAPKAP kinase 2 in Caenorhabditis elegans striated muscle. Mol Biol Cell. 2015;26:2096-111 pubmed publisher

..These results suggest that MAK-1 is an activator of twitchin kinase and that the p38 MAP kinase pathway may be involved in the regulation of twitchin. ..