Gene Symbol: mab-5
Description: Homeobox protein mab-5
Alias: Homeobox protein mab-5
Species: Caenorhabditis elegans

Top Publications

  1. Liu H, Strauss T, Potts M, Cameron S. Direct regulation of egl-1 and of programmed cell death by the Hox protein MAB-5 and by CEH-20, a C. elegans homolog of Pbx1. Development. 2006;133:641-50 pubmed
    ..Direct regulation of programmed cell death may be an evolutionarily ancient and conserved function of Hox genes. ..
  2. Salser S, Kenyon C. A C. elegans Hox gene switches on, off, on and off again to regulate proliferation, differentiation and morphogenesis. Development. 1996;122:1651-61 pubmed
    ..Thus, this Hox gene achieves much of its power to diversify the anteroposterior axis through fine spatiotemporal differences in expression coupled with a changing pattern of cellular response. ..
  3. Harris J, Honigberg L, Robinson N, Kenyon C. Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position. Development. 1996;122:3117-31 pubmed
    ..The Q descendants do not migrate toward any obvious physical targets in wild-type or mutant animals. Therefore, these genes appear to be part of a system that positions the migrating Q descendants along the anteroposterior axis. ..
  4. Ch ng Q, Williams L, Lie Y, Sym M, Whangbo J, Kenyon C. Identification of genes that regulate a left-right asymmetric neuronal migration in Caenorhabditis elegans. Genetics. 2003;164:1355-67 pubmed
    ..Most of these mutants were defective in mab-5 expression in the QL lineage and might identify genes that interact directly or indirectly with the EGL-20/Wnt signaling pathway. ..
  5. Mitani S, Du H, Hall D, Driscoll M, Chalfie M. Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans. Development. 1993;119:773-83 pubmed
  6. Zinovyeva A, Yamamoto Y, Sawa H, Forrester W. Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development. Genetics. 2008;179:1357-71 pubmed publisher
    ..Finally, we find striking differences between the phenotypes of the Wnt quintuple and Frizzled quadruple mutants. ..
  7. Huang X, Tian E, Xu Y, Zhang H. The C. elegans engrailed homolog ceh-16 regulates the self-renewal expansion division of stem cell-like seam cells. Dev Biol. 2009;333:337-47 pubmed publisher
  8. Portman D, Emmons S. The basic helix-loop-helix transcription factors LIN-32 and HLH-2 function together in multiple steps of a C. elegans neuronal sublineage. Development. 2000;127:5415-26 pubmed
    ..During ray development, lin-32 performs roles of proneural, neuronal precursor, and differentiation genes of other systems. ..
  9. Korswagen H, Coudreuse D, Betist M, van de Water S, Zivkovic D, Clevers H. The Axin-like protein PRY-1 is a negative regulator of a canonical Wnt pathway in C. elegans. Genes Dev. 2002;16:1291-302 pubmed
    ..We conclude that a highly divergent destruction complex consisting of PRY-1, SGG-1, and APR-1 regulates BAR-1/beta-catenin signaling in C. elegans. ..

More Information


  1. Hahn A, Emmons S. The roles of an ephrin and a semaphorin in patterning cell-cell contacts in C. elegans sensory organ development. Dev Biol. 2003;256:379-88 pubmed
    ..The evidence indicates that ray identity genes primarily regulate ray morphogenesis by pathways other than through regulation of expression of semaphorin and ephrin. ..
  2. Yu H, Seah A, Sternberg P. Re-programming of C. elegans male epidermal precursor fates by Wnt, Hox, and LIN-12/Notch activities. Dev Biol. 2010;345:1-11 pubmed publisher
    ..p fate specification, indicating that regulation of ectopic HCG fate formation revealed in anterior Pn.p cells reflect mechanisms of pattern formation during normal hook development. ..
  3. Tamayo J, Gujar M, Macdonald S, Lundquist E. Functional transcriptomic analysis of the role of MAB-5/Hox in Q neuroblast migration in Caenorhabditis elegans. BMC Genomics. 2013;14:304 pubmed publisher
    ..The identities of the genes regulated by MAB-5 indicate that MAB-5 acts by modifying interactions with the basement membrane, resulting in posterior versus anterior migration. ..
  4. Wang X, Zhou F, Lv S, Yi P, Zhu Z, Yang Y, et al. Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration. Proc Natl Acad Sci U S A. 2013;110:11175-80 pubmed publisher
    ..Thus, MIG-13 links the Wnt signaling and Hox genes that guide migrations, to the actin cytoskeleton, which executes the motility response in neuronal migration. ..
  5. Josephson M, Chai Y, Ou G, Lundquist E. EGL-20/Wnt and MAB-5/Hox Act Sequentially to Inhibit Anterior Migration of Neuroblasts in C. elegans. PLoS ONE. 2016;11:e0148658 pubmed publisher
    ..In addition to inhibiting anterior migration, MAB-5/Hox also cell-autonomously promotes posterior migration of QL.a (and QR.a in a mab-5 gain-of-function). ..
  6. Josephson M, Miltner A, Lundquist E. Nonautonomous Roles of MAB-5/Hox and the Secreted Basement Membrane Molecule SPON-1/F-Spondin in Caenorhabditis elegans Neuronal Migration. Genetics. 2016;203:1747-62 pubmed publisher
    ..spon-1 expression from BWMs might be part of the posterior patterning necessary for directed Q descendant migration. ..
  7. Maloof J, Kenyon C. The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling. Development. 1998;125:181-90 pubmed
    ..Our findings suggest that in addition to permitting vulval cell divisions to occur, lin-39 is also required to specify the outcome of Ras signaling by selectively activating vulva-specific genes. ..
  8. Gutierrez A, Knoch L, Witte H, Sommer R. Functional specificity of the nematode Hox gene mab-5. Development. 2003;130:983-93 pubmed
    ..elegans paralogous Hox proteins can rescue Cel-mab-5. Experiments with chimeric, truncated and mutagenized Hox proteins suggest the specificity to be conferred by the N-terminal arm and helix I, but not helix II of the homeodomain. ..
  9. Tian C, Shi H, Colledge C, Stern M, Waterston R, Liu J. The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm. Development. 2011;138:1033-43 pubmed publisher
    ..elegans M lineage suggests a possible more general link between Hox-PBC factors and SoxC proteins in regulating cell proliferation. ..