Gene Symbol: mab-3
Description: Protein male abnormal 3
Alias: Protein male abnormal 3
Species: Caenorhabditis elegans
Yi W, Zarkower D. Similarity of DNA binding and transcriptional regulation by Caenorhabditis elegans MAB-3 and Drosophila melanogaster DSX suggests conservation of sex determining mechanisms. Development. 1999;126:873-81 pubmed
..elegans, and it suggests that nematodes and insects use at least some of the same mechanisms to control sexual development. ..
Ross J, Zarkower D. Polycomb group regulation of Hox gene expression in C. elegans. Dev Cell. 2003;4:891-901 pubmed
..Thus, as in Drosophila, vertebrates, and plants, C. elegans PcG proteins regulate key developmental patterning genes to establish positional identity. ..
Pires daSilva A, Sommer R. Finally, worm polycomb-like genes meet Hox regulation. Dev Cell. 2003;4:770-2 pubmed
..elegans. However, sequence comparison indicates that these genes may not be homologous to the fly Polycomb genes, suggesting that independent gene recruitment occurred during nematode evolution. ..
Mason D, Rabinowitz J, Portman D. dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans. Development. 2008;135:2373-82 pubmed publisher
..These findings indicate that an important conserved function of DM genes is to link the general sex determination hierarchy to specific effectors of differentiation and morphogenesis. ..
Goszczynski B, Captan V, Danielson A, Lancaster B, McGhee J. A 44 bp intestine-specific hermaphrodite-specific enhancer from the C. elegans vit-2 vitellogenin gene is directly regulated by ELT-2, MAB-3, FKH-9 and DAF-16 and indirectly regulated by the germline, by daf-2/insulin signaling and by the TGF-Î²/Sma/M. Dev Biol. 2016;413:112-27 pubmed publisher
Raymond C, Shamu C, Shen M, Seifert K, Hirsch B, Hodgkin J, et al
. Evidence for evolutionary conservation of sex-determining genes. Nature. 1998;391:691-5 pubmed
..DMT1 maps to the distal short arm of chromosome 9, a location implicated in human XY sex reversal. Proteins with DM domains may therefore also regulate sexual development in mammals. ..
Ross J, Kalis A, Murphy M, Zarkower D. The DM domain protein MAB-3 promotes sex-specific neurogenesis in C. elegans by regulating bHLH proteins. Dev Cell. 2005;8:881-92 pubmed
..Proteins related to MAB-3 (DM domain proteins) control sexual differentiation in diverse metazoans. We therefore suggest that regulation of Hes genes by DM domain proteins may be a general mechanism for specifying sex-specific neurons. ..
Inoue H, Nishida E. The DM domain transcription factor MAB-3 regulates male hypersensitivity to oxidative stress in Caenorhabditis elegans. Mol Cell Biol. 2010;30:3453-9 pubmed publisher
..These results strongly suggest that the DM domain protein MAB-3 regulates oxidative stress sensitivity by repressing transcription of ELT-2 target genes in the intestine. ..