Gene Symbol: lrp-1
Description: Low-density lipoprotein receptor-related protein
Alias: Low-density lipoprotein receptor-related protein
Species: Caenorhabditis elegans

Top Publications

  1. Yochem J, Tuck S, Greenwald I, Han M. A gp330/megalin-related protein is required in the major epidermis of Caenorhabditis elegans for completion of molting. Development. 1999;126:597-606 pubmed
    ..These observations indicate that LRP-1 is related to megalin not only structurally but also functionally. ..
  2. Kamikura D, Cooper J. Lipoprotein receptors and a disabled family cytoplasmic adaptor protein regulate EGL-17/FGF export in C. elegans. Genes Dev. 2003;17:2798-811 pubmed
    ..These results suggest a model in which Ce-DAB-1 coordinates selection of receptors and cargo, including EGL-17, for transport through the secretory pathway. ..
  3. Roggo L, Bernard V, Kovacs A, Rose A, Savoy F, Zetka M, et al. Membrane transport in Caenorhabditis elegans: an essential role for VPS34 at the nuclear membrane. EMBO J. 2002;21:1673-83 pubmed
    ..Thus, LET-512/VPS34 may regulate the secretory pathway in a much broader range of compartments than was previously suggested for the yeast orthologue. ..
  4. Grigorenko A, Moliaka Y, Soto M, Mello C, Rogaev E. The Caenorhabditis elegans IMPAS gene, imp-2, is essential for development and is functionally distinct from related presenilins. Proc Natl Acad Sci U S A. 2004;101:14955-60 pubmed
    ..These data suggest that IMPs are functionally distinct from related PSs and implicate IMPs as critical regulators of development that may potentially interact with the lipid-lipoprotein receptor-mediated pathway. ..
  5. Kang Y, Yochem J, Bell L, Sorensen E, Chen L, Conner S. Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1. Mol Biol Cell. 2013;24:308-18 pubmed publisher