Gene Symbol: lon-2
Species: Caenorhabditis elegans
Saied Santiago K, Townley R, Attonito J, da Cunha D, Díaz Balzac C, Tecle E, et al
. Coordination of Heparan Sulfate Proteoglycans with Wnt Signaling To Control Cellular Migrations and Positioning in Caenorhabditis elegans. Genetics. 2017;206:1951-1967 pubmed publisher
..Our studies suggest that HSPGs use structurally diverse glycans in coordination with Wnt-signaling pathways to control multiple cellular behaviors, including cellular and axonal migrations and, cellular positioning. ..
Tischler J, Lehner B, Chen N, Fraser A. Combinatorial RNA interference in Caenorhabditis elegans reveals that redundancy between gene duplicates can be maintained for more than 80 million years of evolution. Genome Biol. 2006;7:R69 pubmed
Gumienny T, MacNeil L, Wang H, de Bono M, Wrana J, Padgett R. Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Curr Biol. 2007;17:159-64 pubmed
..This is the first report of a glypican directly interacting with a growth-factor pathway in C. elegans and provides a mechanistic model for glypican regulation of growth-factor pathways...
Wang X, Liu J, Zhu Z, Ou G. The heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblast polarization during migration. Dev Biol. 2015;399:306-14 pubmed publisher
..Heparan sulfate proteoglycans (HSPGs) that carry long chains of differentially modified sugar residues contribute to extracellular matrix; however, the functions of HSPG ..
Liu Z, Shi H, Szymczak L, Aydin T, Yun S, Constas K, et al
. Promotion of bone morphogenetic protein signaling by tetraspanins and glycosphingolipids. PLoS Genet. 2015;11:e1005221 pubmed publisher
Taneja Bageshwar S, Gumienny T. Two functional domains in C. elegans glypican LON-2 can independently inhibit BMP-like signaling. Dev Biol. 2012;371:66-76 pubmed publisher
Blanchette C, Perrat P, Thackeray A, BÃ©nard C. Glypican Is a Modulator of Netrin-Mediated Axon Guidance. PLoS Biol. 2015;13:e1002183 pubmed publisher
..We propose that LON-2/glypican acts as a modulator of UNC-40/DCC-mediated guidance to fine-tune axonal responses to UNC-6/netrin signals during migration. ..