lmn-1

Summary

Gene Symbol: lmn-1
Description: Lamin-1
Alias: Lamin-1
Species: Caenorhabditis elegans
Products:     lmn-1

Top Publications

  1. Liu J, Rolef Ben Shahar T, Riemer D, Treinin M, Spann P, Weber K, et al. Essential roles for Caenorhabditis elegans lamin gene in nuclear organization, cell cycle progression, and spatial organization of nuclear pore complexes. Mol Biol Cell. 2000;11:3937-47 pubmed
    ..Our observations show that lmn-1 is an essential gene in C. elegans, and that the nuclear lamins are involved in chromatin organization, cell cycle progression, chromosome segregation, and correct spacing of NPCs. ..
  2. Liu J, Lee K, Segura Totten M, Neufeld E, Wilson K, Gruenbaum Y. MAN1 and emerin have overlapping function(s) essential for chromosome segregation and cell division in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2003;100:4598-603 pubmed
    ..These findings show that LEM domain proteins are essential for cell division and that Ce-emerin and Ce-MAN1 share at least one and possibly multiple overlapping functions, which may be relevant to Emery-Dreifuss muscular dystrophy...
  3. Haithcock E, Dayani Y, Neufeld E, Zahand A, Feinstein N, Mattout A, et al. Age-related changes of nuclear architecture in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2005;102:16690-5 pubmed
    ..Because the nucleus is vital for many cellular functions, our studies raise the possibility that the nucleus is a prominent focal point for regulating aging. ..
  4. Lee K, Starr D, Cohen M, Liu J, Han M, Wilson K, et al. Lamin-dependent localization of UNC-84, a protein required for nuclear migration in Caenorhabditis elegans. Mol Biol Cell. 2002;13:892-901 pubmed
    ..UNC-84 is not required for centrosome attachment to the nucleus because centrosomes are localized normally in unc-84 hyp7 cells despite a nuclear migration defect. Models for UNC-84 localization are discussed. ..
  5. Karabinos A, Sch√ľnemann J, Meyer M, Aebi U, Weber K. The single nuclear lamin of Caenorhabditis elegans forms in vitro stable intermediate filaments and paracrystals with a reduced axial periodicity. J Mol Biol. 2003;325:241-7 pubmed
    ..C.elegans lamin in low ionic strength Tris-buffers at a pH of 7.2-7.4 provides a stable population of lamin IFs. Some implications of this filament formation are discussed...
  6. Cohen M, Tzur Y, Neufeld E, Feinstein N, Delannoy M, Wilson K, et al. Transmission electron microscope studies of the nuclear envelope in Caenorhabditis elegans embryos. J Struct Biol. 2002;140:232-40 pubmed
    ..Taken together, these results show evolutionarily conserved protein localization, interactions, and functions of the C. elegans nuclear envelope...
  7. Wiesel N, Mattout A, Melcer S, Melamed Book N, Herrmann H, Medalia O, et al. Laminopathic mutations interfere with the assembly, localization, and dynamics of nuclear lamins. Proc Natl Acad Sci U S A. 2008;105:180-5 pubmed
    ..These findings help in understanding the role of individual residues and domains in laminopathy pathology and, eventually, promote the development of therapeutic interventions...
  8. Gorjanacz M, Mattaj I. Lipin is required for efficient breakdown of the nuclear envelope in Caenorhabditis elegans. J Cell Sci. 2009;122:1963-9 pubmed publisher
    ..This Lpin-1 requirement appears to be separable from the effect of Lpin-1 on the peripheral ER. ..
  9. Bank E, Ben Harush K, Wiesel Motiuk N, Barkan R, Feinstein N, Lotan O, et al. A laminopathic mutation disrupting lamin filament assembly causes disease-like phenotypes in Caenorhabditis elegans. Mol Biol Cell. 2011;22:2716-28 pubmed publisher

More Information

Publications13

  1. Mattout A, Pike B, Towbin B, Bank E, Gonzalez Sandoval A, Stadler M, et al. An EDMD mutation in C. elegans lamin blocks muscle-specific gene relocation and compromises muscle integrity. Curr Biol. 2011;21:1603-14 pubmed publisher
    ..It has remained unresolved, however, whether the association of facultative heterochromatin with the nuclear periphery, or its release, has functional relevance for cell or tissue integrity...
  2. Mattout A, Goldberg M, Tzur Y, Margalit A, Gruenbaum Y. Specific and conserved sequences in D. melanogaster and C. elegans lamins and histone H2A mediate the attachment of lamins to chromosomes. J Cell Sci. 2007;120:77-85 pubmed
    ..Taken together, these results suggest that specific residues in lamin Dm0 and histone H2A mediate the attachment of the nuclear lamina to chromosomes in vivo, which could have implications on the understanding of laminopathic diseases. ..
  3. D Angelo M, Raices M, Panowski S, Hetzer M. Age-dependent deterioration of nuclear pore complexes causes a loss of nuclear integrity in postmitotic cells. Cell. 2009;136:284-95 pubmed publisher
  4. Bone C, Tapley E, Gorjanacz M, Starr D. The Caenorhabditis elegans SUN protein UNC-84 interacts with lamin to transfer forces from the cytoplasm to the nucleoskeleton during nuclear migration. Mol Biol Cell. 2014;25:2853-65 pubmed publisher
    ..In this model, SUN/KASH bridges serve as bolts through the nuclear envelope, and nucleoskeleton components LMN-1 and SAMP-1 act as both nuts and washers on the inside of the nucleus. ..