Gene Symbol: lis-1
Description: Lissencephaly-1 homolog
Alias: Lissencephaly-1 homolog
Species: Caenorhabditis elegans
Williams S, Locke C, Braden A, Caldwell K, Caldwell G. Epileptic-like convulsions associated with LIS-1 in the cytoskeletal control of neurotransmitter signaling in Caenorhabditis elegans. Hum Mol Genet. 2004;13:2043-59 pubmed
Cockell M, Baumer K, GONCZY P. lis-1 is required for dynein-dependent cell division processes in C. elegans embryos. J Cell Sci. 2004;117:4571-82 pubmed
..These results suggest that dynein and Lis1, albeit functioning in identical processes, are targeted partially independently of one another. ..
Fortin S, Marshall S, Jaeger E, Greene P, Brady L, Isaac R, et al
. The PAM-1 aminopeptidase regulates centrosome positioning to ensure anterior-posterior axis specification in one-cell C. elegans embryos. Dev Biol. 2010;344:992-1000 pubmed publisher
..We conclude that PAM-1's role in axis polarization is to prevent premature movement of the centrosome from the posterior cortex, ensuring proper axis establishment in the embryo...
Dawe A, Caldwell K, Harris P, Morris N, Caldwell G. Evolutionarily conserved nuclear migration genes required for early embryonic development in Caenorhabditis elegans. Dev Genes Evol. 2001;211:434-41 pubmed
..These results demonstrate that the LIS-1/NUDC-like proteins of C. elegans represent a link between nuclear positioning, cell division, and neuronal function. ..
Locke C, Williams S, Schwarz E, Caldwell G, Caldwell K. Genetic interactions among cortical malformation genes that influence susceptibility to convulsions in C. elegans. Brain Res. 2006;1120:23-34 pubmed
..Thus, interactions among gene products with LIS-1 may mediate intrinsic thresholds of neuronal synchrony. ..
Nguyen Ngoc T, Afshar K, GONCZY P. Coupling of cortical dynein and G alpha proteins mediates spindle positioning in Caenorhabditis elegans. Nat Cell Biol. 2007;9:1294-302 pubmed
..Together with microtubule dynamics, this allows pulling forces to be exerted and proper cell division to be achieved. ..
Buttner E, Gil Krzewska A, Rajpurohit A, Hunter C. Progression from mitotic catastrophe to germ cell death in Caenorhabditis elegans lis-1 mutants requires the spindle checkpoint. Dev Biol. 2007;305:397-410 pubmed
..These results suggest that apoptosis may contribute to the cell-sparse pathology of lissencephaly. ..