lin 44


Gene Symbol: lin 44
Description: Abnormal cell lineage protein 44
Alias: Abnormal cell lineage protein 44
Species: Caenorhabditis elegans

Top Publications

  1. Herman M, Vassilieva L, Horvitz H, Shaw J, Herman R. The C. elegans gene lin-44, which controls the polarity of certain asymmetric cell divisions, encodes a Wnt protein and acts cell nonautonomously. Cell. 1995;83:101-10 pubmed
    ..Our mosaic analysis indicates that lin-44 acts cell nonautonomously. We propose that LIN-44 protein is secreted by tail hypodermal cells and affects the polarity of asymmetric cell divisions that occur more anteriorly in the tail. ..
  2. Herman M, Horvitz H. The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions. Development. 1994;120:1035-47 pubmed
    ..Thus, lin-44 mutants appear to generate polar cells but to misorient these cells along the body axis of the animal. We postulate that lin-44 acts to specify the orientation of polar cells. ..
  3. Rocheleau C, Yasuda J, Shin T, Lin R, Sawa H, Okano H, et al. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell. 1999;97:717-26 pubmed
    ..This activation leads to phosphorylation of POP-1 and to apparent changes in its subcellular localization. Our findings provide evidence for novel regulatory avenues for an evolutionarily conserved Wnt/WG signaling pathway. ..
  4. Pan C, Howell J, Clark S, Hilliard M, Cordes S, Bargmann C, et al. Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans. Dev Cell. 2006;10:367-77 pubmed
    ..Our results indicate that Wnts play a key role in A/P guidance in C. elegans and employ distinct mechanisms to regulate different migrations. ..
  5. Gleason J, Szyleyko E, Eisenmann D. Multiple redundant Wnt signaling components function in two processes during C. elegans vulval development. Dev Biol. 2006;298:442-57 pubmed
    ..p lineage. Here, too, we found that four of five Wnt receptors can influence P7.p orientation, suggesting that a surprising amount of functional redundancy exists in Wnt signaling during C. elegans vulval induction...
  6. Zinovyeva A, Yamamoto Y, Sawa H, Forrester W. Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development. Genetics. 2008;179:1357-71 pubmed publisher
    ..Finally, we find striking differences between the phenotypes of the Wnt quintuple and Frizzled quadruple mutants. ..
  7. Zheng C, Diaz Cuadros M, Chalfie M. Dishevelled attenuates the repelling activity of Wnt signaling during neurite outgrowth in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2015;112:13243-8 pubmed publisher
    ..Our results suggest that Dsh proteins both respond to Wnt signals to shape neuronal projections and moderate its activity to fine-tune neuronal morphology. ..
  8. Mason D, Rabinowitz J, Portman D. dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans. Development. 2008;135:2373-82 pubmed publisher
    ..These findings indicate that an important conserved function of DM genes is to link the general sex determination hierarchy to specific effectors of differentiation and morphogenesis. ..
  9. Yamamoto Y, Takeshita H, Sawa H. Multiple Wnts redundantly control polarity orientation in Caenorhabditis elegans epithelial stem cells. PLoS Genet. 2011;7:e1002308 pubmed publisher
    ..Our results provide a paradigm for understanding how cell polarity is coordinated by extrinsic signals. ..

More Information


  1. Lezzerini M, Budovskaya Y. A dual role of the Wnt signaling pathway during aging in Caenorhabditis elegans. Aging Cell. 2014;13:8-18 pubmed publisher
    ..Our results suggest that Wnt signaling regulates aging-intrinsic genetic pathways, opening a new research direction on the role of Wnt signaling in aging and age-related diseases. ..
  2. Hartin S, Hudson M, Yingling C, Ackley B. A Synthetic Lethal Screen Identifies a Role for Lin-44/Wnt in C. elegans Embryogenesis. PLoS ONE. 2015;10:e0121397 pubmed publisher
    ..Overall, the SynLet phenotype provides a robust platform to identify ptp-3 and sdn-1 interacting genes, as well as other genes that function in development, yet might be missed in traditional forward genetic screens. ..
  3. Poon V, Klassen M, Shen K. UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites. Nature. 2008;455:669-73 pubmed publisher
  4. Kirszenblat L, Pattabiraman D, Hilliard M. LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans Neurons. PLoS Biol. 2011;9:e1001157 pubmed publisher
    ..Taken together, our results reveal a crucial role for Wnt and Frizzled molecules in regulating dendrite development in vivo. ..