lin 41


Gene Symbol: lin 41
Description: Protein lin-41
Alias: Protein lin-41
Species: Caenorhabditis elegans
Products:     lin 41

Top Publications

  1. Cevec M, Thibaudeau C, Plavec J. Solution structure of a let-7 miRNA:lin-41 mRNA complex from C. elegans. Nucleic Acids Res. 2008;36:2330-7 pubmed publisher
    ..The 3D structure of the construct gives insight into the structural aspects of interactions between let-7 miRNA and lin-41 mRNA. ..
  2. Zou Y, Chiu H, Zinovyeva A, Ambros V, Chuang C, Chang C. Developmental decline in neuronal regeneration by the progressive change of two intrinsic timers. Science. 2013;340:372-376 pubmed publisher
    ..These findings show that a let-7-lin-41 regulatory circuit, which was previously shown to control timing of events in mitotic stem cell lineages, is reutilized in postmitotic neurons to control postdifferentiation events...
  3. Slack F, Basson M, Liu Z, Ambros V, Horvitz H, Ruvkun G. The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor. Mol Cell. 2000;5:659-69 pubmed
    ..We suggest that late larval activation of let-7 RNA expression downregulates LIN-41 to relieve inhibition of lin-29. ..
  4. Mason D, Rabinowitz J, Portman D. dmd-3, a doublesex-related gene regulated by tra-1, governs sex-specific morphogenesis in C. elegans. Development. 2008;135:2373-82 pubmed publisher
    ..These findings indicate that an important conserved function of DM genes is to link the general sex determination hierarchy to specific effectors of differentiation and morphogenesis. ..
  5. Tocchini C, Keusch J, Miller S, Finger S, Gut H, Stadler M, et al. The TRIM-NHL protein LIN-41 controls the onset of developmental plasticity in Caenorhabditis elegans. PLoS Genet. 2014;10:e1004533 pubmed publisher
    ..These studies provide the first insight into the mechanism inhibiting the onset of embryonic differentiation in developing oocytes, which is required to ensure a successful transition between generations. ..
  6. Del Rio Albrechtsen T, Kiontke K, Chiou S, Fitch D. Novel gain-of-function alleles demonstrate a role for the heterochronic gene lin-41 in C. elegans male tail tip morphogenesis. Dev Biol. 2006;297:74-86 pubmed
    ..We speculate that small changes affecting LIN-41 could have been significant for male tail evolution. ..
  7. Aeschimann F, Kumari P, Bartake H, Gaidatzis D, Xu L, Ciosk R, et al. LIN41 Post-transcriptionally Silences mRNAs by Two Distinct and Position-Dependent Mechanisms. Mol Cell. 2017;65:476-489.e4 pubmed publisher
    ..Such position-dependent dual activity may, when studied more systematically, emerge as a feature shared by other RBPs. ..
  8. Abrahante J, Daul A, Li M, Volk M, Tennessen J, Miller E, et al. The Caenorhabditis elegans hunchback-like gene lin-57/hbl-1 controls developmental time and is regulated by microRNAs. Dev Cell. 2003;4:625-37 pubmed
    ..Examination of the hb 3'UTR reveals potential binding sites for known fly miRNAs. Thus, evolutionary conservation of hunchback genes may include temporal control of cell fate specification and microRNA-mediated regulation. ..
  9. Solomon A, Mian Y, Ortega Cava C, Liu V, Gurumurthy C, Naramura M, et al. Upregulation of the let-7 microRNA with precocious development in lin-12/Notch hypermorphic Caenorhabditis elegans mutants. Dev Biol. 2008;316:191-9 pubmed publisher
    ..Importantly, the human microRNA let-7a was also upregulated in various human cell lines in response to Notch 1 activation, suggesting an evolutionarily conserved cross-talk between let-7 and the canonical lin-12/Notch signaling pathway. ..

More Information


  1. Spike C, Coetzee D, Nishi Y, Guven Ozkan T, Oldenbroek M, Yamamoto I, et al. Translational control of the oogenic program by components of OMA ribonucleoprotein particles in Caenorhabditis elegans. Genetics. 2014;198:1513-33 pubmed publisher
    ..Taken together, these data support a model in which the conserved regulators of mRNA translation LIN-41 and OMA-1/2 coordinately control oocyte growth and the proper spatial and temporal execution of the meiotic maturation decision. ..
  2. Matsuura R, Ashikawa T, Nozaki Y, Kitagawa D. LIN-41 inactivation leads to delayed centrosome elimination and abnormal chromosome behavior during female meiosis in Caenorhabditis elegans. Mol Biol Cell. 2016;27:799-811 pubmed publisher
    ..Overall, our work provides new insights into the regulation of centrosome behavior to ensure critical meiotic events and the generation of intact oocytes. ..
  3. Tsukamoto T, Gearhart M, Spike C, Huelgas Morales G, Mews M, Boag P, et al. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Genetics. 2017;206:2007-2039 pubmed publisher
    ..Upon their synthesis, SPN-4 and MEG-1 assemble into LIN-41 RNPs prior to their functions in the embryo. This study defines a translational repression-to-activation switch as a key element of cytoplasmic maturation. ..
  4. Kanamoto T, Terada K, Yoshikawa H, Furukawa T. Cloning and regulation of the vertebrate homologue of lin-41 that functions as a heterochronic gene in Caenorhabditis elegans. Dev Dyn. 2006;235:1142-9 pubmed
    ..The 3'UTRs of the mouse and chick lin-41 genes contain multiple let-7 complementary sites. Using luciferase assay, we showed that lin-41 expression can be regulated through let-7 complementary sites. ..
  5. Ecsedi M, Rausch M, Großhans H. The let-7 microRNA directs vulval development through a single target. Dev Cell. 2015;32:335-44 pubmed publisher
    ..Hence, let-7 does not function to reduce gene expression noise broadly, but to direct vulval development through extensive regulation of a single, defined target. ..
  6. Cevec M, Thibaudeau C, Plavec J. NMR structure of the let-7 miRNA interacting with the site LCS1 of lin-41 mRNA from Caenorhabditis elegans. Nucleic Acids Res. 2010;38:7814-21 pubmed publisher