lin 3


Gene Symbol: lin 3
Description: Protein lin-3;hypothetical protein
Alias: Protein lin-3;hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Ferguson E, Horvitz H. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics. 1985;110:17-72 pubmed
    ..Our results suggest that we may have identified most, or all, genes of these two classes...
  2. Davison E, Saffer A, Huang L, Demodena J, Sternberg P, Horvitz H. The LIN-15A and LIN-56 transcriptional regulators interact to negatively regulate EGF/Ras signaling in Caenorhabditis elegans vulval cell-fate determination. Genetics. 2011;187:803-15 pubmed publisher
    ..Furthermore, LIN-56 and LIN-15A interact in the yeast two-hybrid system. We propose that LIN-56 and LIN-15A associate in a nuclear complex that inhibits vulval specification by repressing lin-3 EGF expression...
  3. Thompson B, Lamont L, Kimble J. Germ-line induction of the Caenorhabditis elegans vulva. Proc Natl Acad Sci U S A. 2006;103:620-5 pubmed
    ..Our findings reveal new insights into germ line-to-soma signals and the role of PUF proteins in animal development. ..
  4. Hwang B, Sternberg P. A cell-specific enhancer that specifies lin-3 expression in the C. elegans anchor cell for vulval development. Development. 2004;131:143-51 pubmed
  5. Clandinin T, DeModena J, Sternberg P. Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. Cell. 1998;92:523-33 pubmed
    ..Our results demonstrate that one mechanism by which receptor tyrosine kinases can evoke tissue-specific responses is through activation of distinct signal transduction cascades in different tissues. ..
  6. Chamberlin H, Sternberg P. The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans. Development. 1994;120:2713-21 pubmed
    ..We have also investigated the role of lin-12 in forming the anterior/posterior pattern of fates. A lin-12 gain-of-function defect is masked by redundant positional information from F and U. ..
  7. Hill R, Sternberg P. The gene lin-3 encodes an inductive signal for vulval development in C. elegans. Nature. 1992;358:470-6 pubmed
    ..Expression of lin-3 in the anchor cell stimulates vulval induction; lin-3 may encode the vulval inducing signal...
  8. Cui M, Chen J, Myers T, Hwang B, Sternberg P, Greenwald I, et al. SynMuv genes redundantly inhibit lin-3/EGF expression to prevent inappropriate vulval induction in C. elegans. Dev Cell. 2006;10:667-72 pubmed
  9. Van Buskirk C, Sternberg P. Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nat Neurosci. 2007;10:1300-7 pubmed
    ..Our results reveal an evolutionarily conserved role for EGF signaling in the regulation of behavioral quiescence. ..

More Information


  1. Saffer A, Kim D, van Oudenaarden A, Horvitz H. The Caenorhabditis elegans synthetic multivulva genes prevent ras pathway activation by tightly repressing global ectopic expression of lin-3 EGF. PLoS Genet. 2011;7:e1002418 pubmed publisher
    ..Analogous genes in mammals might function as tumor suppressors by preventing broad ectopic expression of EGF-like ligands. ..
  2. Maloof J, Kenyon C. The Hox gene lin-39 is required during C. elegans vulval induction to select the outcome of Ras signaling. Development. 1998;125:181-90 pubmed
    ..Our findings suggest that in addition to permitting vulval cell divisions to occur, lin-39 is also required to specify the outcome of Ras signaling by selectively activating vulva-specific genes. ..
  3. Horvitz H, Sulston J. Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans. Genetics. 1980;96:435-54 pubmed
    ..Three of the mutants are suppressed by pleiotropic suppressors believed to be specific for null alleles, suggesting that their phenotypes result from the complete absence of gene activity. ..
  4. Fernandes J, Sternberg P. The tailless ortholog nhr-67 regulates patterning of gene expression and morphogenesis in the C. elegans vulva. PLoS Genet. 2007;3:e69 pubmed
    ..We postulate that the differential levels and combinatorial patterns of lin-11, cog-1, and nhr-67 expression are a part of a regulatory code for the mature vulval cell types...
  5. Simms C, Baillie D. A strawberry notch homolog, let-765/nsh-1, positively regulates lin-3/egf expression to promote RAS-dependent vulval induction in C. elegans. Dev Biol. 2010;341:472-85 pubmed publisher
  6. Eisenmann D, Kim S. Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation. Genetics. 1997;146:553-65 pubmed
    ..Our results suggest that a mutation in a human ras gene analogous to ga89 might contribute to oncogenic transformation. ..
  7. Detwiler M, Reuben M, Li X, Rogers E, Lin R. Two zinc finger proteins, OMA-1 and OMA-2, are redundantly required for oocyte maturation in C. elegans. Dev Cell. 2001;1:187-99 pubmed
    ..The Oma prophase arrest is released by inactivation of a MYT-1-like kinase, suggesting that OMA-1 and OMA-2 function upstream of MYT-1 as positive regulators of prophase progression during meiotic maturation. ..
  8. Dutt A, Canevascini S, Froehli Hoier E, Hajnal A. EGF signal propagation during C. elegans vulval development mediated by ROM-1 rhomboid. PLoS Biol. 2004;2:e334 pubmed
    ..These results indicate that, in spite of their structural diversity, Rhomboid proteins play a conserved role in activating EGFR signaling in C. elegans, Drosophila, and possibly also in mammals. ..
  9. Chi W, Reinke V. Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB). Development. 2006;133:3147-57 pubmed
    ..Thus, in vivo, C. elegans E2F directly promotes oogenesis and embryogenesis through the activation of a tissue-specific transcriptional program that does not require LIN-35. ..
  10. Green J, Inoue T, Sternberg P. The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development. 2007;134:4053-62 pubmed
    ..A sequestration model is supported by our findings that the CAM-1 ECD binds to several Wnts in vitro. These results demonstrate how ROR proteins help to refine the spatial pattern of Wnt activity in a complex multicellular environment...
  11. Jiang H, Wu Y. LIN-3/EGF promotes the programmed cell death of specific cells in Caenorhabditis elegans by transcriptional activation of the pro-apoptotic gene egl-1. PLoS Genet. 2014;10:e1004513 pubmed publisher
    ..Our data and the previous cell culture studies that say EGF triggers apoptosis in some cell lines suggest that the EGF-mediated modulation of PCD is likely conserved in C. elegans and humans. ..
  12. Barkoulas M, Vargas Velazquez A, Peluffo A, Felix M. Evolution of New cis-Regulatory Motifs Required for Cell-Specific Gene Expression in Caenorhabditis. PLoS Genet. 2016;12:e1006278 pubmed publisher