lin 25


Gene Symbol: lin 25
Description: Protein lin-25
Alias: Protein lin-25
Species: Caenorhabditis elegans

Top Publications

  1. Ferguson E, Sternberg P, Horvitz H. A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans. Nature. 1987;326:259-67 pubmed
    ..Fifteen of the genes function in a system involved in the intracellular response to the extracellular signal that induces vulval formation...
  2. Tuck S, Greenwald I. lin-25, a gene required for vulval induction in Caenorhabditis elegans. Genes Dev. 1995;9:341-57 pubmed
    ..A decrease in induction also appears to decrease lateral signaling. We have cloned and sequenced the lin-25 gene and shown that it encodes a novel protein that may be a target of the mpk-1/sur-1 MAPK. ..
  3. Nilsson L, Li X, Tiensuu T, Auty R, Greenwald I, Tuck S. Caenorhabditis elegans lin-25: cellular focus, protein expression and requirement for sur-2 during induction of vulval fates. Development. 1998;125:4809-19 pubmed
    ..LIN-25 is also expressed in the lateral hypodermis. Overexpression of LIN-25 disrupts lateral hypodermal cell fusion, suggesting that lin-25 may play a role in regulating cell fusions in C. elegans. ..
  4. Nilsson L, Tiensuu T, Tuck S. Caenorhabditis elegans lin-25: a study of its role in multiple cell fate specification events involving Ras and the identification and characterization of evolutionarily conserved domains. Genetics. 2000;156:1083-96 pubmed
    ..We discuss how lin-25 might act in cell fate specification in C. elegans within the context of models for lin-25 function in cell identity and cell signaling. ..
  5. Nicholas H, Hodgkin J. The ERK MAP kinase cascade mediates tail swelling and a protective response to rectal infection in C. elegans. Curr Biol. 2004;14:1256-61 pubmed
    ..elegans from severe constipation, which would otherwise arrest development and cause sterility. Involvement in pathogen defense represents a new role for ERK MAP kinase signaling in this organism. ..
  6. Ferguson E, Horvitz H. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics. 1985;110:17-72 pubmed
    ..Our results suggest that we may have identified most, or all, genes of these two classes...
  7. Howard R, Sundaram M. C. elegans EOR-1/PLZF and EOR-2 positively regulate Ras and Wnt signaling and function redundantly with LIN-25 and the SUR-2 Mediator component. Genes Dev. 2002;16:1815-27 pubmed
    ..Further studies of eor-1 and eor-2 may provide insight into the roles of PLZF in normal development and leukemogenesis. ..