Genomes and Genes
Gene Symbol: lin 17
Description: hypothetical protein
Species: Caenorhabditis elegans
- Green J, Inoue T, Sternberg P. The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development. 2007;134:4053-62 pubmed..A sequestration model is supported by our findings that the CAM-1 ECD binds to several Wnts in vitro. These results demonstrate how ROR proteins help to refine the spatial pattern of Wnt activity in a complex multicellular environment...
- Kirszenblat L, Pattabiraman D, Hilliard M. LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans Neurons. PLoS Biol. 2011;9:e1001157 pubmed publisher..Taken together, our results reveal a crucial role for Wnt and Frizzled molecules in regulating dendrite development in vivo. ..
- Unsoeld T, Park J, Hutter H. Discoidin domain receptors guide axons along longitudinal tracts in C. elegans. Dev Biol. 2013;374:142-52 pubmed publisher..Our results provide the first insight on discoidin domain receptor function in invertebrates and establish a novel role for discoidin domain receptors in axon navigation and axon tract formation. ..
- Jensen M, Hoerndli F, Brockie P, Wang R, Johnson E, Maxfield D, et al. Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system. Cell. 2012;149:173-87 pubmed publisher..Using optogenetic nerve stimulation, we demonstrate activity-dependent synaptic plasticity and its dependence on ACR-16/?7 translocation mediated by Wnt signaling via LIN-17/CAM-1 heteromeric receptors. ..
- Deshpande R, Inoue T, Priess J, Hill R. lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development. Dev Biol. 2005;278:118-29 pubmed..These experiments suggest that Wnt signaling pathways reorient cell lineages in the posterior half of the vulva from a default orientation displayed in the anterior half of the vulva. ..
- Siegfried K, Kidd A, Chesney M, Kimble J. The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad. Genetics. 2004;166:171-86 pubmed..We suggest that sys-3 is a new key gene in this pathway and that gon-14, gon-15, and gon-16 may cooperate with POP-1 and SYS-1 at multiple stages of gonad development. ..
- Gupta B, Sternberg P. Tissue-specific regulation of the LIM homeobox gene lin-11 during development of the Caenorhabditis elegans egg-laying system. Dev Biol. 2002;247:102-15 pubmed..Finally, we provide evidence that the regulation of lin-11 by LIN-12/Notch signaling is directly mediated by the Su(H)/CBF1 family member LAG-1. ..
- Rocheleau C, Yasuda J, Shin T, Lin R, Sawa H, Okano H, et al. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell. 1999;97:717-26 pubmed..This activation leads to phosphorylation of POP-1 and to apparent changes in its subcellular localization. Our findings provide evidence for novel regulatory avenues for an evolutionarily conserved Wnt/WG signaling pathway. ..
- Ferguson E, Horvitz H. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics. 1985;110:17-72 pubmed..Our results suggest that we may have identified most, or all, genes of these two classes...
- Steimel A, Wong L, Najarro E, Ackley B, Garriga G, Hutter H. The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans. Development. 2010;137:3663-73 pubmed publisher..Our findings indicate that FMI-1 is a cell-type dependent axon guidance factor with different domain requirements for its different functions in pioneers and followers. ..
- Jiang L, Sternberg P. An HMG1-like protein facilitates Wnt signaling in Caenorhabditis elegans. Genes Dev. 1999;13:877-89 pubmed..The sequence nonspecific HMG protein SON-1 and the sequence specific HMG protein POP-1 might both act in the Wnt responding cells to regulate gene transcription in opposite directions. ..