lin 17


Gene Symbol: lin 17
Description: hypothetical protein
Species: Caenorhabditis elegans

Top Publications

  1. Maro G, Klassen M, Shen K. A beta-catenin-dependent Wnt pathway mediates anteroposterior axon guidance in C. elegans motor neurons. PLoS ONE. 2009;4:e4690 pubmed publisher
    ..Together, our data provide evidence that Wnt-mediated axon guidance can be transduced through a beta-catenin-dependent pathway. ..
  2. Wu M, Herman M. A novel noncanonical Wnt pathway is involved in the regulation of the asymmetric B cell division in C. elegans. Dev Biol. 2006;293:316-29 pubmed
    ..We conclude that a noncanonical Wnt pathway, which is different from other Wnt pathways in C. elegans, regulates B cell polarity. ..
  3. Sawa H, Lobel L, Horvitz H. The Caenorhabditis elegans gene lin-17, which is required for certain asymmetric cell divisions, encodes a putative seven-transmembrane protein similar to the Drosophila frizzled protein. Genes Dev. 1996;10:2189-97 pubmed
  4. Harris J, Honigberg L, Robinson N, Kenyon C. Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position. Development. 1996;122:3117-31 pubmed
    ..The Q descendants do not migrate toward any obvious physical targets in wild-type or mutant animals. Therefore, these genes appear to be part of a system that positions the migrating Q descendants along the anteroposterior axis. ..
  5. Zinovyeva A, Yamamoto Y, Sawa H, Forrester W. Complex network of Wnt signaling regulates neuronal migrations during Caenorhabditis elegans development. Genetics. 2008;179:1357-71 pubmed publisher
    ..Finally, we find striking differences between the phenotypes of the Wnt quintuple and Frizzled quadruple mutants. ..
  6. Wu M, Herman M. Asymmetric localizations of LIN-17/Fz and MIG-5/Dsh are involved in the asymmetric B cell division in C. elegans. Dev Biol. 2007;303:650-62 pubmed
    ..Functions of the MIG-5 DEP, PDZ and DIX domains were also conserved. Thus, a novel PCP-like pathway, in which LIN-17 and MIG-5 are asymmetrically localized, is involved in the regulation of B cell polarity. ..
  7. Sternberg P, Horvitz H. lin-17 mutations of Caenorhabditis elegans disrupt certain asymmetric cell divisions. Dev Biol. 1988;130:67-73 pubmed
    ..The lin-17 gene product is involved in asymmetric cell divisions in a variety of tissues, indicating that lin-17 functions in a general mechanism for the establishment of cellular asymmetry in parent cells. ..
  8. Herman M, Horvitz H. The Caenorhabditis elegans gene lin-44 controls the polarity of asymmetric cell divisions. Development. 1994;120:1035-47 pubmed
    ..Thus, lin-44 mutants appear to generate polar cells but to misorient these cells along the body axis of the animal. We postulate that lin-44 acts to specify the orientation of polar cells. ..
  9. Pan C, Howell J, Clark S, Hilliard M, Cordes S, Bargmann C, et al. Multiple Wnts and frizzled receptors regulate anteriorly directed cell and growth cone migrations in Caenorhabditis elegans. Dev Cell. 2006;10:367-77 pubmed
    ..Our results indicate that Wnts play a key role in A/P guidance in C. elegans and employ distinct mechanisms to regulate different migrations. ..

More Information


  1. Green J, Inoue T, Sternberg P. The C. elegans ROR receptor tyrosine kinase, CAM-1, non-autonomously inhibits the Wnt pathway. Development. 2007;134:4053-62 pubmed
    ..A sequestration model is supported by our findings that the CAM-1 ECD binds to several Wnts in vitro. These results demonstrate how ROR proteins help to refine the spatial pattern of Wnt activity in a complex multicellular environment...
  2. Poon V, Klassen M, Shen K. UNC-6/netrin and its receptor UNC-5 locally exclude presynaptic components from dendrites. Nature. 2008;455:669-73 pubmed publisher
  3. Kirszenblat L, Pattabiraman D, Hilliard M. LIN-44/Wnt directs dendrite outgrowth through LIN-17/Frizzled in C. elegans Neurons. PLoS Biol. 2011;9:e1001157 pubmed publisher
    ..Taken together, our results reveal a crucial role for Wnt and Frizzled molecules in regulating dendrite development in vivo. ..
  4. Unsoeld T, Park J, Hutter H. Discoidin domain receptors guide axons along longitudinal tracts in C. elegans. Dev Biol. 2013;374:142-52 pubmed publisher
    ..Our results provide the first insight on discoidin domain receptor function in invertebrates and establish a novel role for discoidin domain receptors in axon navigation and axon tract formation. ..
  5. Jensen M, Hoerndli F, Brockie P, Wang R, Johnson E, Maxfield D, et al. Wnt signaling regulates acetylcholine receptor translocation and synaptic plasticity in the adult nervous system. Cell. 2012;149:173-87 pubmed publisher
    ..Using optogenetic nerve stimulation, we demonstrate activity-dependent synaptic plasticity and its dependence on ACR-16/?7 translocation mediated by Wnt signaling via LIN-17/CAM-1 heteromeric receptors. ..
  6. Deshpande R, Inoue T, Priess J, Hill R. lin-17/Frizzled and lin-18 regulate POP-1/TCF-1 localization and cell type specification during C. elegans vulval development. Dev Biol. 2005;278:118-29 pubmed
    ..These experiments suggest that Wnt signaling pathways reorient cell lineages in the posterior half of the vulva from a default orientation displayed in the anterior half of the vulva. ..
  7. Siegfried K, Kidd A, Chesney M, Kimble J. The sys-1 and sys-3 genes cooperate with Wnt signaling to establish the proximal-distal axis of the Caenorhabditis elegans gonad. Genetics. 2004;166:171-86 pubmed
    ..We suggest that sys-3 is a new key gene in this pathway and that gon-14, gon-15, and gon-16 may cooperate with POP-1 and SYS-1 at multiple stages of gonad development. ..
  8. Gupta B, Sternberg P. Tissue-specific regulation of the LIM homeobox gene lin-11 during development of the Caenorhabditis elegans egg-laying system. Dev Biol. 2002;247:102-15 pubmed
    ..Finally, we provide evidence that the regulation of lin-11 by LIN-12/Notch signaling is directly mediated by the Su(H)/CBF1 family member LAG-1. ..
  9. Rocheleau C, Yasuda J, Shin T, Lin R, Sawa H, Okano H, et al. WRM-1 activates the LIT-1 protein kinase to transduce anterior/posterior polarity signals in C. elegans. Cell. 1999;97:717-26 pubmed
    ..This activation leads to phosphorylation of POP-1 and to apparent changes in its subcellular localization. Our findings provide evidence for novel regulatory avenues for an evolutionarily conserved Wnt/WG signaling pathway. ..
  10. Ferguson E, Horvitz H. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics. 1985;110:17-72 pubmed
    ..Our results suggest that we may have identified most, or all, genes of these two classes...
  11. Steimel A, Wong L, Najarro E, Ackley B, Garriga G, Hutter H. The Flamingo ortholog FMI-1 controls pioneer-dependent navigation of follower axons in C. elegans. Development. 2010;137:3663-73 pubmed publisher
    ..Our findings indicate that FMI-1 is a cell-type dependent axon guidance factor with different domain requirements for its different functions in pioneers and followers. ..
  12. Jiang L, Sternberg P. An HMG1-like protein facilitates Wnt signaling in Caenorhabditis elegans. Genes Dev. 1999;13:877-89 pubmed
    ..The sequence nonspecific HMG protein SON-1 and the sequence specific HMG protein POP-1 might both act in the Wnt responding cells to regulate gene transcription in opposite directions. ..