Gene Symbol: lgg-3
Description: Ubiquitin-like protein ATG12
Alias: Ubiquitin-like protein ATG12
Species: Caenorhabditis elegans

Top Publications

  1. Hars E, Qi H, Ryazanov A, Jin S, Cai L, Hu C, et al. Autophagy regulates ageing in C. elegans. Autophagy. 2007;3:93-5 pubmed
    ..elegans using RNAi. We showed that RNAi shortened the lifespan of both wild type and daf-2 mutant C. elegans, providing strong support for a role of autophagy in ageing regulation. ..
  2. Samara C, Syntichaki P, Tavernarakis N. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ. 2008;15:105-12 pubmed
    ..Our findings demonstrate that autophagy contributes to cellular destruction during necrosis. Thus, interfering with the autophagic process may protect neurons against necrotic damage in humans. ..
  3. Mosbech M, Kruse R, Harvald E, Olsen A, Gallego S, Hannibal Bach H, et al. Functional loss of two ceramide synthases elicits autophagy-dependent lifespan extension in C. elegans. PLoS ONE. 2013;8:e70087 pubmed publisher
    ..elegans lifespan. We propose that loss of HYL-1 and LAGR-1 result in dietary restriction-induced autophagy and consequently prolonged longevity. ..