lgg-1

Summary

Gene Symbol: lgg-1
Description: Protein lgg-1
Alias: Protein lgg-1
Species: Caenorhabditis elegans

Top Publications

  1. Melendez A, Talloczy Z, Seaman M, Eskelinen E, Hall D, Levine B. Autophagy genes are essential for dauer development and life-span extension in C. elegans. Science. 2003;301:1387-91 pubmed
    ..elegans orthologs of the yeast autophagy genes APG1, APG7, APG8, and AUT10. Thus, autophagy is a cellular pathway essential for dauer development and life-span extension in C. elegans. ..
  2. Manil Ségalen M, Lefebvre C, Jenzer C, Trichet M, Boulogne C, Satiat Jeunemaitre B, et al. The C. elegans LC3 acts downstream of GABARAP to degrade autophagosomes by interacting with the HOPS subunit VPS39. Dev Cell. 2014;28:43-55 pubmed publisher
    ..The duplications of Atg8 in metazoans thus allowed the acquisition of specialized functions for autophagosome maturation. ..
  3. Tóth M, Simon P, Kovacs A, Vellai T. Influence of autophagy genes on ion-channel-dependent neuronal degeneration in Caenorhabditis elegans. J Cell Sci. 2007;120:1134-41 pubmed
    ..Our findings reveal a role for autophagy genes in neuronal cell loss in C. elegans. ..
  4. Samara C, Syntichaki P, Tavernarakis N. Autophagy is required for necrotic cell death in Caenorhabditis elegans. Cell Death Differ. 2008;15:105-12 pubmed
    ..Our findings demonstrate that autophagy contributes to cellular destruction during necrosis. Thus, interfering with the autophagic process may protect neurons against necrotic damage in humans. ..
  5. Ghavidel A, Baxi K, Ignatchenko V, Prusinkiewicz M, Arnason T, Kislinger T, et al. A Genome Scale Screen for Mutants with Delayed Exit from Mitosis: Ire1-Independent Induction of Autophagy Integrates ER Homeostasis into Mitotic Lifespan. PLoS Genet. 2015;11:e1005429 pubmed publisher
    ..Our data provide evidence that catabolism of protein aggregates, a natural byproduct of high protein synthesis and turn over in dividing cells, is among the drivers of mitotic longevity in eukaryotes. ..
  6. O Rourke E, Kuballa P, Xavier R, Ruvkun G. ?-6 Polyunsaturated fatty acids extend life span through the activation of autophagy. Genes Dev. 2013;27:429-40 pubmed publisher
    ..We propose that the salubrious effects of dietary supplementation with ?-3/6 PUFAs (fish oils) that have emerged from epidemiological studies in humans may be due to a similar activation of autophagic programs. ..
  7. Schipanski A, Lange S, Segref A, Gutschmidt A, Lomas D, Miranda E, et al. A novel interaction between aging and ER overload in a protein conformational dementia. Genetics. 2013;193:865-76 pubmed publisher
    ..These data suggest that targets aimed at increasing UPR capacity in neurons are valuable tools for therapeutic intervention. ..
  8. Troulinaki K, Tavernarakis N. Endocytosis and intracellular trafficking contribute to necrotic neurodegeneration in C. elegans. EMBO J. 2012;31:654-66 pubmed publisher
    ..These findings demonstrate a prominent role for endocytosis in cellular destruction during neurodegeneration, which is likely conserved in metazoans. ..
  9. Wu F, Watanabe Y, Guo X, Qi X, Wang P, Zhao H, et al. Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy. Mol Cell. 2015;60:914-29 pubmed publisher
    ..Our study reveals the differential function of two ATG8 homologs in autophagy during C. elegans development. ..

More Information

Publications18

  1. Al Rawi S, Louvet Vallee S, Djeddi A, Sachse M, Culetto E, Hajjar C, et al. Postfertilization autophagy of sperm organelles prevents paternal mitochondrial DNA transmission. Science. 2011;334:1144-7 pubmed publisher
  2. Lapierre L, Gelino S, Melendez A, Hansen M. Autophagy and lipid metabolism coordinately modulate life span in germline-less C. elegans. Curr Biol. 2011;21:1507-14 pubmed publisher
    ..Collectively, our data offer a novel mechanism by which autophagy and the lipase LIPL-4 interdependently modulate aging in germline-deficient C. elegans by maintaining lipid homeostasis to prolong life span. ..
  3. Zhang Y, Yan L, Zhou Z, Yang P, Tian E, Zhang K, et al. SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans. Cell. 2009;136:308-21 pubmed publisher
    ..Our study reveals a mechanism for preferential degradation of protein aggregates by autophagy and emphasizes the physiological significance of selective autophagy during animal development. ..
  4. Erdélyi P, Borsos E, Takacs Vellai K, Kovacs T, Kovacs A, Sigmond T, et al. Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. J Cell Sci. 2011;124:1510-8 pubmed publisher
    ..The identification of apoptosis and autophagy as compensatory cellular pathways in C. elegans might help us to understand how dysregulated PCD in humans can lead to diverse pathologies, including cancer, neurodegeneration and diabetes. ..
  5. Palikaras K, Lionaki E, Tavernarakis N. Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans. Nature. 2015;521:525-8 pubmed publisher
    ..Uncoupling of these two processes during ageing contributes to overproliferation of damaged mitochondria and decline of cellular function. ..
  6. Robida Stubbs S, Glover Cutter K, Lamming D, Mizunuma M, Narasimhan S, Neumann Haefelin E, et al. TOR signaling and rapamycin influence longevity by regulating SKN-1/Nrf and DAF-16/FoxO. Cell Metab. 2012;15:713-24 pubmed publisher
    ..We conclude that modulation of SKN-1/Nrf and DAF-16/FoxO may be generally important in the effects of TOR signaling in vivo and that these transcription factors mediate an opposing relationship between growth signals and longevity. ..
  7. Zhang P, Zhang H. Autophagy modulates miRNA-mediated gene silencing and selectively degrades AIN-1/GW182 in C. elegans. EMBO Rep. 2013;14:568-76 pubmed publisher
    ..Thus, autophagy activity modulates miRNA-mediated gene silencing and degrades a core miRISC component. ..
  8. Visvikis O, Ihuegbu N, Labed S, Luhachack L, Alves A, Wollenberg A, et al. Innate host defense requires TFEB-mediated transcription of cytoprotective and antimicrobial genes. Immunity. 2014;40:896-909 pubmed publisher
    ..Thus, our data suggest that TFEB is a previously unappreciated, evolutionarily ancient transcription factor in the host response to infection. ..
  9. Alberti A, Michelet X, Djeddi A, Legouis R. The autophagosomal protein LGG-2 acts synergistically with LGG-1 in dauer formation and longevity in C. elegans. Autophagy. 2010;6:622-33 pubmed publisher
    ..Finally, we demonstrate that both LGG-2 and LGG-1 act synergistically and are involved in dauer formation and longevity of the worm. ..