Gene Symbol: lev 1
Description: Acetylcholine receptor subunit beta-type lev-1;hypothetical protein
Alias: Acetylcholine receptor subunit beta-type lev-1;hypothetical protein
Species: Caenorhabditis elegans
Culetto E, Baylis H, Richmond J, Jones A, Fleming J, Squire M, et al
. The Caenorhabditis elegans unc-63 gene encodes a levamisole-sensitive nicotinic acetylcholine receptor alpha subunit. J Biol Chem. 2004;279:42476-83 pubmed
..Thus, at least four subunits, two alpha types (UNC-38 and UNC-63) and two non-alpha types (UNC-29 and LEV-1), can contribute to levamisole-sensitive muscle nAChRs in nematodes. ..
Gottschalk A, Schafer W. Visualization of integral and peripheral cell surface proteins in live Caenorhabditis elegans. J Neurosci Methods. 2006;154:68-79 pubmed
..This showed that, theoretically, any molecular interaction of sufficient affinity may be used to specifically label cell surface structures in live nematodes. ..
Lewis J, Wu C, Berg H, Levine J. The genetics of levamisole resistance in the nematode Caenorhabditis elegans. Genetics. 1980;95:905-28 pubmed
..elegans. And, as the most resistant class of mutants might lack pharmacologically functional acetyl-choline receptors (LEWIS et al. 1980), these mutants may also be of some neurobiological significance. ..
Kim J, Poole D, Waggoner L, Kempf A, Ramirez D, Treschow P, et al
. Genes affecting the activity of nicotinic receptors involved in Caenorhabditis elegans egg-laying behavior. Genetics. 2001;157:1599-610 pubmed
Qian H, Robertson A, Powell Coffman J, Martin R. Levamisole resistance resolved at the single-channel level in Caenorhabditis elegans. FASEB J. 2008;22:3247-54 pubmed publisher
..Our observations provide an explanation for levamisole resistance produced by LEV-8 and LEV-1 mutants at the single-channel level. ..
Jospin M, Qi Y, Stawicki T, Boulin T, Schuske K, Horvitz H, et al
. A neuronal acetylcholine receptor regulates the balance of muscle excitation and inhibition in Caenorhabditis elegans. PLoS Biol. 2009;7:e1000265 pubmed publisher
..These data indicate that the ACR-2 receptor is important for the coordinated excitation and inhibition of body muscles underlying sinusoidal movement. ..