Gene Symbol: let-92
Description: Serine/threonine-protein phosphatase 2A catalytic subunit
Alias: Serine/threonine-protein phosphatase 2A catalytic subunit
Species: Caenorhabditis elegans

Top Publications

  1. Schlaitz A, Srayko M, Dammermann A, Quintin S, Wielsch N, MacLeod I, et al. The C. elegans RSA complex localizes protein phosphatase 2A to centrosomes and regulates mitotic spindle assembly. Cell. 2007;128:115-27 pubmed
    ..By regulating a subset of PP2A functions at the centrosome, the RSA complex could therefore provide a means of coordinating microtubule outgrowth from centrosomes and kinetochore microtubule stability during mitotic spindle assembly. ..
  2. Song M, Liu Y, Anderson D, Jahng W, O Connell K. Protein phosphatase 2A-SUR-6/B55 regulates centriole duplication in C. elegans by controlling the levels of centriole assembly factors. Dev Cell. 2011;20:563-71 pubmed publisher
    ..Together, our findings indicate that PP2A-SUR-6 promotes centriole assembly by protecting ZYG-1 and SAS-5 from degradation. ..
  3. Anders K, Grimson A, Anderson P. SMG-5, required for C.elegans nonsense-mediated mRNA decay, associates with SMG-2 and protein phosphatase 2A. EMBO J. 2003;22:641-50 pubmed
    ..Our results suggest that PP2A is the SMG-2 phosphatase, and the role of SMG-5 is to direct PP2A to its SMG-2 substrate. We discuss cycles of SMG-2 phosphorylation and their roles in NMD. ..
  4. Kao G, Tuck S, Baillie D, Sundaram M. C. elegans SUR-6/PR55 cooperates with LET-92/protein phosphatase 2A and promotes Raf activity independently of inhibitory Akt phosphorylation sites. Development. 2004;131:755-65 pubmed
    ..In addition to their roles in Ras signaling, SUR-6/PR55 and LET-92/PP2A-C cooperate to control mitotic progression during early embryogenesis. ..
  5. Parry D, Xu J, Ruvkun G. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Curr Biol. 2007;17:2013-22 pubmed
  6. Vora S, Phillips B. Centrosome-Associated Degradation Limits β-Catenin Inheritance by Daughter Cells after Asymmetric Division. Curr Biol. 2015;25:1005-16 pubmed publisher
    ..Based on our observations of centrosomal SYS-1 dynamics, we discuss the possibility that the centrosome may coordinate various cell-cycle-dependent processes by synchronizing mitosis and protein regulation. ..
  7. Ogura K, Okada T, Mitani S, Gengyo Ando K, Baillie D, Kohara Y, et al. Protein phosphatase 2A cooperates with the autophagy-related kinase UNC-51 to regulate axon guidance in Caenorhabditis elegans. Development. 2010;137:1657-67 pubmed publisher
    ..This is the first report of a serine/threonine protein phosphatase functioning in axon guidance in vivo. ..
  8. Asencio C, Davidson I, Santarella Mellwig R, Ly Hartig T, Mall M, Wallenfang M, et al. Coordination of kinase and phosphatase activities by Lem4 enables nuclear envelope reassembly during mitosis. Cell. 2012;150:122-35 pubmed publisher
    ..By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4/LEM-4L controls postmitotic NE formation in a function conserved from worms to humans. ..
  9. Lange K, Heinrichs J, Cheung K, Srayko M. Suppressor mutations identify amino acids in PAA-1/PR65 that facilitate regulatory RSA-1/B? subunit targeting of PP2A to centrosomes in C. elegans. Biol Open. 2013;2:88-94 pubmed publisher
    ..In the context of previously published results, these data propose a mechanism of how different PP2A B-regulatory subunit families can bind the same holoenzyme in a mutually exclusive manner, to perform specific tasks in vivo. ..