Genomes and Genes
Gene Symbol: let-23
Description: Receptor protein-tyrosine kinase;Receptor tyrosine-protein kinase let-23
Alias: Receptor protein-tyrosine kinase;Receptor tyrosine-protein kinase let-23
Species: Caenorhabditis elegans
- Chamberlin H, Sternberg P. The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans. Development. 1994;120:2713-21 pubmed..We have also investigated the role of lin-12 in forming the anterior/posterior pattern of fates. A lin-12 gain-of-function defect is masked by redundant positional information from F and U. ..
- Poulin G, Ahringer J. The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells. BMC Dev Biol. 2010;10:109 pubmed publisher..g. LIN-12 (Notch) could be regulated by this ubiquitin ligase complex. This work has uncovered a novel function for the CUL-4/DDB-1/CDT-2 E3 ligase that may be relevant for its mammalian oncogenic activity. ..
- Moghal N, Garcia L, Khan L, Iwasaki K, Sternberg P. Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein Galphaq and excitable cells in C. elegans. Development. 2003;130:4553-66 pubmed
- Yin X, Gower N, Baylis H, Strange K. Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans. Mol Biol Cell. 2004;15:3938-49 pubmed..Calcium entry may function to trigger Ca(2+) release via IP(3) receptors and/or refill intracellular Ca(2+) stores. ..
- Aroian R, Koga M, Mendel J, Ohshima Y, Sternberg P. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature. 1990;348:693-9 pubmed
- Eisenmann D, Kim S. Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation. Genetics. 1997;146:553-65 pubmed..Our results suggest that a mutation in a human ras gene analogous to ga89 might contribute to oncogenic transformation. ..
- Katz W, Lesa G, Yannoukakos D, Clandinin T, Schlessinger J, Sternberg P. A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog. Mol Cell Biol. 1996;16:529-37 pubmed..The fates produced depended on the copy number of the mutation, suggesting that quantitative differences in receptor activity influence the decision between these two fates. ..
- Van Buskirk C, Sternberg P. Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nat Neurosci. 2007;10:1300-7 pubmed..Our results reveal an evolutionarily conserved role for EGF signaling in the regulation of behavioral quiescence. ..
- Herman R. Crossover suppressors and balanced recessive lethals in Caenorhabditis elegans. Genetics. 1978;88:49-65 pubmed..The frequencies of occurrence of lethals and steriles were approximately equal. Fourteen mutations were assigned to complementation groups and mapped. They tended to map in the same region where LGII visibles are clustered. ..
- Skorobogata O, Escobar Restrepo J, Rocheleau C. An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction. PLoS Genet. 2014;10:e1004728 pubmed publisher..Thus, an AGEF-1/Arf GTPase/AP-1 ensemble functions opposite the LIN-2/7/10 complex to antagonize LET-23 EGFR basolateral membrane localization and signaling. ..