Gene Symbol: let-23
Description: Receptor protein-tyrosine kinase;Receptor tyrosine-protein kinase let-23
Alias: Receptor protein-tyrosine kinase;Receptor tyrosine-protein kinase let-23
Species: Caenorhabditis elegans

Top Publications

  1. Haag A, Gutierrez P, B├╝hler A, Walser M, Yang Q, Langouet M, et al. An in vivo EGF receptor localization screen in C. elegans Identifies the Ezrin homolog ERM-1 as a temporal regulator of signaling. PLoS Genet. 2014;10:e1004341 pubmed publisher
    ..The regulation of receptor localization thus serves to fine-tune the temporal activation of intracellular signaling pathways. ..
  2. Whitfield C, Benard C, Barnes T, Hekimi S, Kim S. Basolateral localization of the Caenorhabditis elegans epidermal growth factor receptor in epithelial cells by the PDZ protein LIN-10. Mol Biol Cell. 1999;10:2087-100 pubmed
    ..LIN-10 may function in secretion of LET-23 to the basolateral membrane domain, or it may be involved in tethering LET-23 at the basolateral plasma membrane once it is secreted. ..
  3. Aroian R, Sternberg P. Multiple functions of let-23, a Caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction. Genetics. 1991;128:251-67 pubmed
    ..Since various let-23 mutant phenotypes can be obtained independently, the let-23 gene is likely to have tissue-specific functions. ..
  4. Ferguson E, Horvitz H. Identification and characterization of 22 genes that affect the vulval cell lineages of the nematode Caenorhabditis elegans. Genetics. 1985;110:17-72 pubmed
    ..Our results suggest that we may have identified most, or all, genes of these two classes...
  5. Skorobogata O, Rocheleau C. RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans. PLoS ONE. 2012;7:e36489 pubmed publisher
    ..Failure to downregulate EGFR signaling contributes to oncogenesis, and thus Rab7 could possess tumor suppressor activity in humans...
  6. Simske J, Kaech S, Harp S, Kim S. LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction. Cell. 1996;85:195-204 pubmed
    ..These results suggest that proper localization of LET-23 receptor to the Pn.p cell junctions is required for signaling activity. ..
  7. Kaech S, Whitfield C, Kim S. The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells. Cell. 1998;94:761-71 pubmed
    ..Each of the binding interactions within this complex is conserved, suggesting that this complex may also mediate basolateral localization in mammals. ..
  8. Clandinin T, DeModena J, Sternberg P. Inositol trisphosphate mediates a RAS-independent response to LET-23 receptor tyrosine kinase activation in C. elegans. Cell. 1998;92:523-33 pubmed
    ..Our results demonstrate that one mechanism by which receptor tyrosine kinases can evoke tissue-specific responses is through activation of distinct signal transduction cascades in different tissues. ..
  9. Stetak A, Hoier E, Croce A, Cassata G, Di Fiore P, Hajnal A. Cell fate-specific regulation of EGF receptor trafficking during Caenorhabditis elegans vulval development. EMBO J. 2006;25:2347-57 pubmed
    ..Extracellular signals thus regulate EGFR trafficking in a cell type-specific manner to control pattern formation during organogenesis. ..

More Information


  1. Chamberlin H, Sternberg P. The lin-3/let-23 pathway mediates inductive signalling during male spicule development in Caenorhabditis elegans. Development. 1994;120:2713-21 pubmed
    ..We have also investigated the role of lin-12 in forming the anterior/posterior pattern of fates. A lin-12 gain-of-function defect is masked by redundant positional information from F and U. ..
  2. Poulin G, Ahringer J. The Caenorhabditis elegans CDT-2 ubiquitin ligase is required for attenuation of EGFR signalling in vulva precursor cells. BMC Dev Biol. 2010;10:109 pubmed publisher
    ..g. LIN-12 (Notch) could be regulated by this ubiquitin ligase complex. This work has uncovered a novel function for the CUL-4/DDB-1/CDT-2 E3 ligase that may be relevant for its mammalian oncogenic activity. ..
  3. Moghal N, Garcia L, Khan L, Iwasaki K, Sternberg P. Modulation of EGF receptor-mediated vulva development by the heterotrimeric G-protein Galphaq and excitable cells in C. elegans. Development. 2003;130:4553-66 pubmed
  4. Yin X, Gower N, Baylis H, Strange K. Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans. Mol Biol Cell. 2004;15:3938-49 pubmed
    ..Calcium entry may function to trigger Ca(2+) release via IP(3) receptors and/or refill intracellular Ca(2+) stores. ..
  5. Aroian R, Koga M, Mendel J, Ohshima Y, Sternberg P. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature. 1990;348:693-9 pubmed
  6. Eisenmann D, Kim S. Mechanism of activation of the Caenorhabditis elegans ras homologue let-60 by a novel, temperature-sensitive, gain-of-function mutation. Genetics. 1997;146:553-65 pubmed
    ..Our results suggest that a mutation in a human ras gene analogous to ga89 might contribute to oncogenic transformation. ..
  7. Katz W, Lesa G, Yannoukakos D, Clandinin T, Schlessinger J, Sternberg P. A point mutation in the extracellular domain activates LET-23, the Caenorhabditis elegans epidermal growth factor receptor homolog. Mol Cell Biol. 1996;16:529-37 pubmed
    ..The fates produced depended on the copy number of the mutation, suggesting that quantitative differences in receptor activity influence the decision between these two fates. ..
  8. Van Buskirk C, Sternberg P. Epidermal growth factor signaling induces behavioral quiescence in Caenorhabditis elegans. Nat Neurosci. 2007;10:1300-7 pubmed
    ..Our results reveal an evolutionarily conserved role for EGF signaling in the regulation of behavioral quiescence. ..
  9. Herman R. Crossover suppressors and balanced recessive lethals in Caenorhabditis elegans. Genetics. 1978;88:49-65 pubmed
    ..The frequencies of occurrence of lethals and steriles were approximately equal. Fourteen mutations were assigned to complementation groups and mapped. They tended to map in the same region where LGII visibles are clustered. ..
  10. Skorobogata O, Escobar Restrepo J, Rocheleau C. An AGEF-1/Arf GTPase/AP-1 ensemble antagonizes LET-23 EGFR basolateral localization and signaling during C. elegans vulva induction. PLoS Genet. 2014;10:e1004728 pubmed publisher
    ..Thus, an AGEF-1/Arf GTPase/AP-1 ensemble functions opposite the LIN-2/7/10 complex to antagonize LET-23 EGFR basolateral membrane localization and signaling. ..