let 19

Summary

Gene Symbol: let 19
Description: Mediator of RNA polymerase II transcription subunit 13
Alias: Mediator of RNA polymerase II transcription subunit 13
Species: Caenorhabditis elegans

Top Publications

  1. Wang J, Walker A, Blackwell T, Yamamoto K. The Caenorhabditis elegans ortholog of TRAP240, CeTRAP240/let-19, selectively modulates gene expression and is essential for embryogenesis. J Biol Chem. 2004;279:29270-7 pubmed
    ..Interestingly, whereas this interaction has been conserved from yeast to mammals, the subcomplex modulates metazoan-specific genetic pathways, likely in addition to those also controlled in yeast. ..
  2. Yoda A, Kouike H, Okano H, Sawa H. Components of the transcriptional Mediator complex are required for asymmetric cell division in C. elegans. Development. 2005;132:1885-93 pubmed
    ..These results suggest that LET-19 and DPY-22 in the Mediator complex repress the transcription of Wnt target genes. ..
  3. Clayton J, van den Heuvel S, Saito R. Transcriptional control of cell-cycle quiescence during C. elegans development. Dev Biol. 2008;313:603-13 pubmed
    ..These transcriptional regulators represent potential molecular connections between development and the basic cell-cycle machinery. ..
  4. Grants J, Ying L, Yoda A, You C, Okano H, Sawa H, et al. The Mediator Kinase Module Restrains Epidermal Growth Factor Receptor Signaling and Represses Vulval Cell Fate Specification in Caenorhabditis elegans. Genetics. 2016;202:583-99 pubmed publisher
    ..Collectively, these data offer an explanation for CKM repression of EGFR signaling output and ectopic vulva formation and provide the first evidence of Mediator CKM-tail module subunit crosstalk in animals. ..