knl-1

Summary

Gene Symbol: knl-1
Description: Kinetochore null protein 1
Alias: Kinetochore null protein 1
Species: Caenorhabditis elegans

Top Publications

  1. Desai A, Rybina S, MULLER REICHERT T, Shevchenko A, Shevchenko A, Hyman A, et al. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans. Genes Dev. 2003;17:2421-35 pubmed
    ..Thus, KNL-1 plays a central role in translating the initiation of kinetochore assembly by CeCENP-A and CeCENP-C into the formation of a functional microtubule-binding interface. ..
  2. Cheeseman I, Niessen S, Anderson S, Hyndman F, Yates J, Oegema K, et al. A conserved protein network controls assembly of the outer kinetochore and its ability to sustain tension. Genes Dev. 2004;18:2255-68 pubmed
    ..Thus, this protein network is a conserved constituent of the outer kinetochore, and the functions defined by our analysis in C. elegans are likely to be widely relevant. ..
  3. Gassmann R, Essex A, Hu J, Maddox P, Motegi F, Sugimoto A, et al. A new mechanism controlling kinetochore-microtubule interactions revealed by comparison of two dynein-targeting components: SPDL-1 and the Rod/Zwilch/Zw10 complex. Genes Dev. 2008;22:2385-99 pubmed publisher
  4. Welburn J, Vleugel M, Liu D, Yates J, Lampson M, Fukagawa T, et al. Aurora B phosphorylates spatially distinct targets to differentially regulate the kinetochore-microtubule interface. Mol Cell. 2010;38:383-92 pubmed publisher
    ..In total, rather than generating exclusively binary changes in microtubule binding, our results suggest a mechanism for the tension-dependent fine-tuning of kinetochore-microtubule interactions. ..
  5. Moyle M, Kim T, Hattersley N, Espeut J, Cheerambathur D, Oegema K, et al. A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached kinetochores to initiate the spindle checkpoint. J Cell Biol. 2014;204:647-57 pubmed publisher
    ..These results delineate an interaction between BUB-1 and MAD-1 that targets MAD-1-MAD-2 complexes to kinetochores and is essential for spindle checkpoint signaling. ..
  6. Cheeseman I, Chappie J, Wilson Kubalek E, Desai A. The conserved KMN network constitutes the core microtubule-binding site of the kinetochore. Cell. 2006;127:983-97 pubmed
    ..Based on these findings, we propose that the conserved KMN network constitutes the core microtubule-binding site of the kinetochore. ..
  7. Yamamoto T, Watanabe S, Essex A, Kitagawa R. SPDL-1 functions as a kinetochore receptor for MDF-1 in Caenorhabditis elegans. J Cell Biol. 2008;183:187-94 pubmed publisher
    ..In addition, SPDL-1 coimmunoprecipitates with MDF-1/MAD1 in vivo. These results suggest that SPDL-1 functions in a kinetochore receptor of MDF-1/MAD1 to induce SAC function. ..
  8. Dumont J, Oegema K, Desai A. A kinetochore-independent mechanism drives anaphase chromosome separation during acentrosomal meiosis. Nat Cell Biol. 2010;12:894-901 pubmed publisher
    ..We suggest that separation is controlled by a meiosis-specific chromosomal domain to coordinate cohesin removal and chromosome segregation. ..
  9. Kern D, Kim T, Rigney M, Hattersley N, Desai A, Cheeseman I. The outer kinetochore protein KNL-1 contains a defined oligomerization domain in nematodes. Mol Biol Cell. 2015;26:229-37 pubmed publisher
    ..elegans. In C. elegans, KNL-1 oligomerization may coordinate with other kinetochore activities to ensure the proper organization, function, and sensory capabilities of the kinetochore-microtubule attachment. ..

More Information

Publications12

  1. Espeut J, Lara Gonzalez P, Sassine M, Shiau A, Desai A, Abrieu A. Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation. Cell Rep. 2015;12:58-65 pubmed publisher
    ..Thus, the finding that PLK-1 functionally substitutes for Mps1 in checkpoint initiation in C. elegans uncovered a role for Plk1 in species that have Mps1. ..
  2. Moore L, Stanvitch G, Roth M, Rosen D. HCP-4/CENP-C promotes the prophase timing of centromere resolution by enabling the centromere association of HCP-6 in Caenorhabditis elegans. Mol Cell Biol. 2005;25:2583-92 pubmed
    ..This result suggests that normal prophase centromere resolution is mediated by condensin II proteins, which are actively recruited to sister centromeres to mediate the process of resolution. ..
  3. Monen J, Maddox P, Hyndman F, Oegema K, Desai A. Differential role of CENP-A in the segregation of holocentric C. elegans chromosomes during meiosis and mitosis. Nat Cell Biol. 2005;7:1248-55 pubmed
    ..These findings highlight a pronounced difference between the segregation of holocentric chromosomes during meiosis and mitosis and demonstrate the potential to uncouple assembly of outer-kinetochore proteins from CENP-A chromatin. ..