Gene Symbol: kin-2
Description: cAMP-dependent protein kinase regulatory subunit
Alias: cAMP-dependent protein kinase regulatory subunit
Species: Caenorhabditis elegans
Schade M, Reynolds N, Dollins C, Miller K. Mutations that rescue the paralysis of Caenorhabditis elegans ric-8 (synembryn) mutants activate the G alpha(s) pathway and define a third major branch of the synaptic signaling network. Genetics. 2005;169:631-49 pubmed
..Our results appear to link RIC-8 (synembryn) and a third major G alpha pathway, the G alpha(s) pathway, with the previously discovered G alpha(o) and G alpha(q) pathways of the synaptic signaling network. ..
Lu X, Gross R, Bagchi S, Rubin C. Cloning, structure, and expression of the gene for a novel regulatory subunit of cAMP-dependent protein kinase in Caenorhabditis elegans. J Biol Chem. 1990;265:3293-303 pubmed
..The 8-kilobase pair C. elegans R gene is divided into 8 exons by introns ranging from 46 to 4300 base pairs. The 5'-flanking region has no TATA box and contains preferred and minor transcription start sites...
Govindan J, Cheng H, Harris J, Greenstein D. Galphao/i and Galphas signaling function in parallel with the MSP/Eph receptor to control meiotic diapause in C. elegans. Curr Biol. 2006;16:1257-68 pubmed
..elegans, highlighting contrasts and parallels between MSP signaling in C. elegans and luteinizing hormone signaling in mammals. ..
Hu S, Pawson T, Steven R. UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway. Genetics. 2011;189:137-51 pubmed publisher
..Together, these data suggest UNC-73 RhoGEF-2 isoforms are required for proper neurotransmitter signaling and may function in the DCV-mediated neuromodulatory regulation of locomotion rate. ..
Fievet B, Rodriguez J, Naganathan S, Lee C, Zeiser E, Ishidate T, et al
. Systematic genetic interaction screens uncover cell polarity regulators and functional redundancy. Nat Cell Biol. 2013;15:103-12 pubmed publisher
..Similar systematic genetic interaction screens for other biological processes will help uncover the inventory of relevant genes and their patterns of interactions. ..
Stein G, Murphy C. C. elegans positive olfactory associative memory is a molecularly conserved behavioral paradigm. Neurobiol Learn Mem. 2014;115:86-94 pubmed publisher
..Study of STAM and ITAM in C. elegans could lead to a more general understanding of the distinctions between these important processes and also to the discovery of novel conserved memory regulators. ..
Lee J, Kong J, Jang J, Han J, Ji Y, Lee J, et al
. Lipid droplet protein LID-1 mediates ATGL-1-dependent lipolysis during fasting in Caenorhabditis elegans. Mol Cell Biol. 2014;34:4165-76 pubmed publisher
..These data suggest the importance of the concerted action of lipase and lipid droplet protein in the response to fasting signals via PKA to maintain lipid homeostasis. ..